Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Fc-gamma-RI"”.
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Expression and characterisation of biopharmaceuticals in heterologous expression systems
… of the high-affinity receptor for human IgG, Fc-gamma-RI (CD64), were successfully established and optimised for heterologous expression in plants, bacteria and mammalian. The first aim of this thesis was the establishment of a protocol for the expression and purification of the anti-HIV …
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Leveraging Antibodies for Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Cancer
… models of cancer. This work can be described as two-fold. In the first part, we investigated how the use of a glycans-specific bioconjugation strategy affects Fc gamma RI binding and why it results in improved <em>in vivo </em>performance of immunoconjugates. To do so, we used the …
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Engineering therapeutic proteins for immune modulation
… antibodies. This interaction is mediated through Fc gamma receptor (Fc[gamma]R) binding to the antibody Fc. Activating and inhibitory Fc[gamma]Rs are expressed on immune cells and bind to the Fc regions of IgGs, which either promote or hinder responses against the tumor cell. Since mouse models of …