Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Fc receptor"”.
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… of my research project was to characterize Fc receptor expression in epithelial cell models of the lower female genital tract with a particular focus on the neonatal Fc receptor (FcRn). Fc receptors are a large family of proteins that bind to the Fc region of immunoglobulins (Igs) and …
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Transepithelial transport of nanoparticles targeted to the neonatal Fc receptor for oral delivery applications
… efficient oral delivery of NPs. The neonatal Fc receptor (FcRn) mediates IgG antibody transport across epithelial barriers. It was discovered as the receptor in the neonatal intestine that transports IgG in breast milk from mother to offspring. However, FcRn is expressed into adulthood at …
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The development of peptide-based inhibitors of the low affinity Fc receptor, Fc [gamma] RIIa
FcyRIIa is an activatory receptor and contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain, involved in the initiation of signalling events. There is now strong evidence from transgenic mouse models and human genetic susceptibility studies that implicate …
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Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function
The neonatal Fc receptor, FcRn, is expressed in many different cell types and serves several functions, some of which are cell type-specific. A function common to most cell types that express this receptor is salvage of IgG from cellular degradation which is responsible for the long in vivo …
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Rational engineering strategies to improve antibody fragment pharmacokinetics and bioavailability
… including an inability to bind the neonatal Fc receptor (FcRn) – the receptor responsible for the long half-lives of natural IgG and serum albumin. A common approach to circumvent these limitations is to enable engagement with the half-life extending neonatal Fc receptor (FcRn). This is …
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The in vitro effects of chemokines on microglia: Implications for multiple sclerosis.
… of nitrite production, superoxide secretion and Fc receptor expression. The majority of the chemokines tested were able to increase superoxide and nitrite production as well as Fc receptor expression with the exception of the beta chemokine, RANTES, whereby only CHME3 cells produced a significant …
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Investigating the role of kidney mononuclear phagocytes in immune complex-induced inflammation.
… in their localization within the organ, IgG Fc receptor expression, and their ability to survey the circulation and present MHC II-peptide complexes, the latter varying with IgG opsonization and IgG IC size. In autoimmune inflammation, one minor subset of F4/80hi CD11blow cells, referred to …
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Identification of the Role of P-Rex1 and its Adaptor Functions in Neutrophils
… particles and supports both integrin- and Fc receptor-dependent uptake independently of its Rac-GEF activity. Furthermore, P-Rex1 facilitates the Fc receptor-mediated activation of Rac and Syk. To investigate the underlying mechanism by which P-Rex1 mediates GPCR trafficking, we found that …
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Smac Mimetic and Combination Immunotherapy for the Treatment of Urothelial Cell Carcinoma
… curing all tested subjects of MB49. I verified Fc receptor-dependent intratumoural regulatory T cell depletion as a required mechanism for enhancing survival probability with the combination of SM and anti-CTLA-4. The further evaluation of mechanisms responsible for SMs stimulating immunity will …
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… pro-inflammatory pathways as well as increased Fc receptor activation following OncoD-0J1 infection. Single-cell RNA sequencing and flow cytometric analysis of F4/80+ cells isolated from infected tumors showed a shift from tumor-supporting TAMs to inflammatory macrophages upon OncoD-0J1 …
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Alternate pathways of cytotoxic T lymphocyte and natural killer cell activation
… redirect CTl-mediated lysis to antigen-negative Fc receptor-positive target cells. Similar redirected lysis was also inducible using mAb MEL - 14, directed against the lymphocyte homing receptor for endothelium (gp - 90MEL-14). The redirected lysis induced by mAbs 9F3 and MEl-14 in the CTL was …
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THE FUNCTIONAL REGULATION OF FCRN EXPRESSION AND FCRN-MEDIATED ANTIGEN PRESENTATION
The neonatal Fc receptor for IgG (FcRn), a major histocompatibility complex (MHC) class I-related molecule, plays an important role in IgG transport and protection. The transport of IgG across epithelial and endothelial barriers and the IgG homeostasis maintained by FcRn contributes to the …
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Selective Degradation of Aggregated Tau Protein Via Vectored Nanobody-TRIM21 RING Fusion Constructs
… they are bound and degraded by the intracellular Fc receptor and E3 ubiquitin ligase TRIM21. It was therefore hypothesised that intracellular aggregated tau could be targeted for degradation by exploiting this TRIM21 pathway. This thesis describes the development of TRIMinators, vectored …
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
… antibody-bound viruses. It requires TRIM21, an Fc receptor and E3 ubiquitin ligase that resides in the cytosol. Binding of TRIM21 to the exposed Fc portion of an antibody that is bound to an internalised virus results in ubiquitin signalling and proteasomal degradation of the virus. Viruses are …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… (GEF) Vav-1 is a regulator of lymphocyte antigen receptor signaling and mediates normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. …
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Augmenting Natural Killer cell antibody binding to enhance ovarian and prostate tumor cell killing via ADCC
… (ADCC). ADCC is exclusively mediated by the IgG Fcγ receptor (FcγR) CD16A, and many clinically successful therapeutic monoclonal antibodies (mAbs) utilize ADCC as a mechanism of action to eradicate tumor cells. However, CD16A binds IgG with low affinity and is rapidly cleaved by ADAM17 upon …
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Studies on the interaction of a single domain of protein G from streptococcus with human Fc and Fab
Protein G (SpG) is a Type III bacterial Fc receptor that binds selectively and non-antigenically to both the Fc and Fab regions of IgG. Here studies are described aimed at understanding the individual contributions to complex stability made by amino acid residues known to make contacts with either …
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Modeling approaches to characterize the disposition of monoclonal antibodies
… non-specific elimination involving the neonatal Fc receptor (FcRn) and endogenous IgG (IgGendo). The remarkable discrepancy between the simplicity of biodistribution data and the complexity of published PBPK models translates in parameter identifiability issues. In this thesis, we address this …
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Engineering the antibody-TRIM21 interface for the improved intracellular clearance of pathogenic targets
… by neurons and degraded via the intracellular Fc receptor and E3 ubiquitin ligase TRIM21, and that passive tau immunotherapy requires this pathway for in vivo efficacy. These findings indicate that enhancing antibody engagement with TRIM21 could substantially improve efficacy yet engineering …
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