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Showing 1 to 2 of 2 for “"Fc glycoforms"”.
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Interrogation and Manipulation of the IGG FC Glycan
… of a given antibody's fragment crystallizable (Fc) domain, which interfaces with cells of the immune system. Often considered a constant region, the immunoglobulin G (IgG) Fc protein backbone and conserved N-linked glycan combine to introduce structural diversity in IgG molecules that in turn, …
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Applicability of Using Physical Stability Data and Advanced Visualization Methods in Protein Comparability Studies
… glycosylation patterns of an IgG1 mAb and Fc molecules) structural differences between proteins. In addition, for the IgG1 Fc glycoforms expressed in yeast, the effect of N-linked glycosylation site occupancy, as well as the effect of different charge states in various nonglycosylated …