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Showing 1 to 8 of 8 for “"Fc gamma receptors"”.

  1. Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia

    Morse, Joshua, <p>0000-0002-9834-1975</p>2026

    … targeting this receptor, which makes use of an Fc gamma receptor scaffolding mechanism to interact with its target. This mechanism is specific to antibodies targeting cells of the hematopoietic lineage, which possess Fc gamma receptors. It has been described in the literature as antigenic …

    uthsc Repository record

  2. THE FUNCTIONAL REGULATION OF FCRN EXPRESSION AND FCRN-MEDIATED ANTIGEN PRESENTATION

    Liu, Xindong2009

    The neonatal Fc receptor for IgG (FcRn), a major histocompatibility complex (MHC) class I-related molecule, plays an important role in IgG transport and protection. The transport of IgG across epithelial and endothelial barriers and the IgG homeostasis maintained by FcRn contributes to the …

    maryland Repository record

  3. Engineering aglycosylated antibody variants with immune effector functions

    Sazinsky, Stephen L. (Stephen Lael)Massachusetts Institute of Technology2009

    … - mediated by the interaction of the conserved Fc regions of the antibody with the Fc gamma receptors (Fc[gamma]Rs) on immune cells - is critical to the efficacy of several. This thesis describes the engineering of antibody Fc domain interactions with Fc[gamma]Rs, using the' yeast S. cerevisiae. …

    mit Repository record

  4. Antibody-Mediated Modulation of Polyclonal Immune Responses

    Cipolla, Melissa2028

    … capability was largely independent of complement receptors 1 and 2 (CR1/2) but was instead dependent on interactions with Fc gamma receptors (FcγRs). Both immunohistochemistry and flow cytometry revealed that infused antibody generated immune complexes (ICs)are retained across the lymph node on …

    rockefeller Repository record

  5. DISSECTING THE ROLE OF THE TETRASPANIN MS4A4A IN MODULATING MACROPHAGE PLASTICITY AND FUNCTION

    TROILO, ALESSIAUniversità degli Studi di Milano2026

    … with and modulate the activity of various immunoreceptors, such as pattern recognition receptors (PRRs) and Ig receptors. MS4A4A is selectively expressed by macrophages, and its expression is upregulated upon treatment with Interleukin-4 (IL-4) and glucocorticoids (Dexamethasone, Dex). However, …

    milano Repository record

  6. Investigation of novel therapeutic strategies in B cell and antibody mediated disease

    Banham, GemmaUniversity of Cambridge2019

    … and dendritic cells (DCs), via ligation of Fc gamma receptors (FcγR), that bind the Fc region of IgG. FcγR-dependent MNP activation results in profound changes in gene expression that mediate antibody effector function in these cells. The resulting inflammatory response can be pathological …

    cambridge Repository record

  7. Engineering therapeutic proteins for immune modulation

    Chen, Tiffany F. (Tiffany Fen-yi)Massachusetts Institute of Technology2014

    … antibodies. This interaction is mediated through Fc gamma receptor (Fc[gamma]R) binding to the antibody Fc. Activating and inhibitory Fc[gamma]Rs are expressed on immune cells and bind to the Fc regions of IgGs, which either promote or hinder responses against the tumor cell. Since mouse models of …

    mit Repository record

  8. C-reactive protein mediated Fc-gamma-receptor signal transduction is enhanced by low density lipoprotein in human macrophages

    Li, KefeiUniversität Ulm

    ulm-diss Repository record