Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Fc gamma receptor"”.
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Ensemble methods in computational protein and ligand design : applications to the Fc[gamma] immunoglobulin, HIV-1 protease, and ketol-acid reductoisomerase systems
… screened energetics of immunoglobulin G (IgG):Fc[gamma] receptor binding using molecular mechanics, Poisson-Boltzmann surface area (MMPBSA) models. We assess the role IgG1 linked glycans play in binding to human Fc[gamma]-III and computationally evaluate experimentally designed Fe mutations …
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… AML.</p> <p>Leukocyte immunoglobulin-like receptor B4 (LILRB4) is an immune checkpoint expressed specifically on the cell surface of monocytic AML with limited expression on other cell types, making it an excellent target for antibody-based precision therapy. We have developed an antibody …
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Roles of CCAAT/enhancer-binding protein [beta] and [-delta] in immunoglobulin G immune complex-induced Inflammation
… -&delta in inflammatory responses elicited by Fc&gamma receptor (Fc&gammaR) activation. Here I showed that C/EBP&beta and -&delta activation were induced in immunoglobulin G immune complex (IgG IC)-treated macrophages by using gel shift assays. The increased expression of C/EBP&beta and -&delta …
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Immunological boosting and personalization of oncolytic virotherapies for cancer treatment
… 200 cancer patients treated with OAds for two Fc gamma receptor (FcγR) polymorphisms to determine if these polymorphisms would affect the responsiveness to the treatments. We observed a certain FcγR genotype combination (FcγRIIIa-VV + FcγRIIa-HR) to be predictive of poor overall survival after …
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Investigation of Interleukin 1B synthesis and secretion by dendritic cells: Interplay between toll-like receptor and FCG receptor
… moDCs. The increase was mediated through P2X7 receptor-dependent Ca2+ influx. In addition, Rac1, JNK and MEK were identified as key molecules in LPS/imIgG-induced IL-1I? production and secretion by moDCs, whilst PI3-K and p38 MAPK as negative modulators.
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Engineering therapeutic proteins for immune modulation
… antibodies. This interaction is mediated through Fc gamma receptor (Fc[gamma]R) binding to the antibody Fc. Activating and inhibitory Fc[gamma]Rs are expressed on immune cells and bind to the Fc regions of IgGs, which either promote or hinder responses against the tumor cell. Since mouse models of …
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A study of the contribution of mast cells to vaccination - Regulatory functions of Fc gamma receptors
… potentially able to activate mast cells through Fc receptors. Indeed, CTA1-DD, in combination with polyclonal IgG, induced mast cell degranulation and the production of TNF-alpha, a cytokine important for the maturation and migration of antigen presenting cells, resulting in enhanced …
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Generation and therapeutic evaluation of recombinant immunotherapeutics on CD64+ monocytic cell lines and polarized ex vivo differentiated human macrophages
… Previous literature and research have identified Fc gamma receptor I (FcγRI)/CD64 as a significant therapeutic target. CD64 is a transmembrane surface receptor found exclusively in myeloid lineage cells such as monocytes and different macrophage subtypes. Hence, protein engineering and …
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Ethanol Impairs Mechanisms of Macrophage Phagocytosis and Cytokine Production
… recovery by 24 hours. To investigate a single receptor pathway, we focused on Fcgamma-receptor (FcgammaR) mediated phagocytosis. In ethanol treated murine AMs and the RAW264.7 cells, phagocytosis of IgG-coated beads demonstrated a 40 and 50% reduction in actin recruitment to the site of the …