Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"FcεRI"”.
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Interleukin-10 Suppresses Mast Cell IgE Receptor Expression And Signaling In Vitro And In Vivo
… To examine Interleukin-10 mediated regulation of FcεRI expression and related downstream signaling molecules, and to determine how this affects mast cell function in vitro and in vivo.Methods: Mast cell FcεRI expression was evaluated with and without IL-10 treatment in human lung and skin mast …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
In addition to high-affinity IgE receptor (FcεRI), a subtype of mast cells (MCs) found primarily in human skin, expresses a G protein-coupled receptor (GPCR) known as MRGPRX2 (mouse counterpart MrgprB2). Following agonist stimulation, GPCRs couple to G proteins to cause cellular activation but most …
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Polymorphisms of High-affinity IgE Receptor Genes in Patients with Aspirin-Intolerant Chronic Urticaria
… urticaria. The high-affinity receptor for IgE (FcεRI) expressed on mast cells and basophils plays a critical role in mediating allergic reactions induced by antigen-specific IgE antibody bindings. FcεRI is composed of three subunits: the IgE-binding α-chain, a signal-augmenting β-chain, and a …
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New aspects of tissue mast cells in inflammatory airway diseases
… through the high-affinity receptor for IgE (FcεRI), rapidly produce and secrete many of the mediators responsible for the typical symptoms in urticaria, asthma and rhinitis. However, increasing amount of data show that mast cells have important, even vital, roles in host defence against …
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Spatiotemporal modeling and model restructuration approaches in studies of intracellular signalling pathways
… framework has been used for the investigation FcεRI aggregation which is an important signaling pathway for immune cells. Using the spatial modeling framework, FcεRI aggregation in the presence of trivalent antigen showed consistent results with current experimental studies. Secondly, the …
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Effect of phosphorylcholine-based small molecule analogues of the immunomodulatory nematode product ES-62 on mast cell function
… away from the high affinity receptor for IgE, FcεRI. In this work, PKC-α was found to be critical for mast cell degranulation and its degradation provided a mechanism for the ES-62-mediated disruption of key PLD-SPHK-dependent pathways of calcium, PKC and NF-кB activation. These data raised the …
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Dissecting the anti-allergic potential of carnosic acid during IgE and IL-33-mediated mast cell activation
… inflammation. Allergen-induced cross-linkage of FcεRI complexes initiates a biphasic mast cell response, characterized by the immediate degranulation of preformed mediators and the delayed production and release of pro-inflammatory cytokine and chemokines. As a result of mast cells being the main …
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Untersuchungen zur Expression der Oberflächenmarker CD63 und CD203c basophiler Granulozyten bei Bienen- und Wespengiftallergikern mit Hilfe des Basophilen Aktivierungstestes (BAT)
… Expression von CD63 v.a. allergen-induziert und FcεRI-vermittelt beobachtet werden. CD203c ist ein hochspezifischer Marker für die basophile Differenzierungslinie. Nach Allergenstimulation wird eine rasche Expression von CD203c beobachtet, welche FcεRI-vermittelt ist. Am Ausmaß der Expression von …
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Cloning, Expression, and Characterization of Ara h 3, a Major Peanut Allergen
<p>Abstract There are eight foods that contribute to food allergies in the western world and peanut is the most common. Currently, there are no medical treatments that can cure an individual of food allergy, so avoidance of the allergic food is the only option. In the United States, there are three …