Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Fcγ receptor"”.
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Kinetic analysis of Fcγ receptor and T cell receptor interacting with respective ligands
Low affinity Fcg receptor III (FcgRIII, CD16) triggers a variety of cellular events upon binding to the Fc portion of IgG. A real-time flow cytometry method was developed to measure the affinity and kinetics of such low affinity receptor/ligand interactions, which was shown as an easily operated …
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Characterisation of the Effect and Functional Significance of Fcγ Receptor Crosslinking on Metabolic Processes in Macrophages
… molecules of the adaptive humoral immune system. Fcγ receptors (FcγRs) mediate the cellular functions of IgG antibodies and are expressed on most immune cells including macrophages. FcγR cross-linking induced by IgG immune complexes (ICs) is important for defence against some infections but can …
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Augmenting Natural Killer cell antibody binding to enhance ovarian and prostate tumor cell killing via ADCC
… (ADCC). ADCC is exclusively mediated by the IgG Fcγ receptor (FcγR) CD16A, and many clinically successful therapeutic monoclonal antibodies (mAbs) utilize ADCC as a mechanism of action to eradicate tumor cells. However, CD16A binds IgG with low affinity and is rapidly cleaved by ADAM17 upon …
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Interrogation and Manipulation of the IGG FC Glycan
… of the glycan and its presence on the B cell receptor (BCR) provokes questions of its possible role in the generation of antibody responses. In the first part of this thesis, I identify a novel class of synthetic nanobodies that can distinguish glycoforms without reactivity to off-target …
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Investigating the spatiotemporal dynamics of mononuclear phagocytes in solid tumours.
… MHC, with different capacities for endocytosis, Fcγ-receptor- mediated phagocytosis and cytokine production. Both mdTAM subsets quickly undergo anti- inflammatory gene expression changes, but this is attenuated by ICB, which also promotes IFNγ-driven chemokine signalling from TAMs to enhance T …