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Showing 1 to 20 of 46 for “"Fatty Acid Synthase"”.
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FATTY ACID SYNTHASE MODULATES MAMMARY GLAND LACTATION AND PROSTATE CANCER PROGRESSION IN VIVO
Fatty acid synthesis is the process of producing de novo fatty acids from carbohydrate and protein carbon sources. The enzyme responsible for this task is appropriately termed Fatty Acid Synthase (FASN). FASN is ubiquitously expressed throughout the body, but because fatty acid synthesis is a very …
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Functional Analysis of Dehydratase Domains of a Polyunsaturated fatty acid Synthase from Thraustochytrium sp. by Mutagenesis
Very long chain polyunsaturated fatty acids (VLCPUFAs), such as docosahexaenoic acid (DHA, 22:6-4,7,10,13,16,19) and eicosapentaenoic acid (EPA, 20:5-5,8,11,14,17), are essential for humans and animals since they are parts of the cell membrane and are involved in mediating various physiological …
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Utilization of Proton Pump Inhibitors in Combination Regimen for Breast Cancer Treatment by Targeting Fatty Acid Synthase
Fatty acid synthase (FASN) over-expression has been associated with poor prognosis and recurrence in cancer patients. In addition, it has also been found that overexpression of FASN causes resistance to DNA-damaging treatments by up-regulating the non-homologous end joining (NHEJ) repair of DNA …
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UNCOVERING THE MOLECULAR BASIS FOR FATTY ACID SYNTHASE PRODUCT SPECIFICITY: STRUCTURAL AND KINETIC EVALUATION OF THIOESTERASE I AND THIOESTERASE II
Fatty acid synthase (FASN) is a multifunctional homodimeric enzyme solely responsible for the synthesis long chain fatty acids (LCFAs) de novo. Fatty acids, and their lipid derivatives, are critical components of all cellular biological processes, including energy storage and utilization, membrane …
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Fatty acid synthase is a major polypeptide constituent of cytosolic lipoprotein and is associated with components of the milk lipid secretory pathway
… of this lipoprotein aggregate was the monomer of fatty acid synthase (FAS). The major milk lipid globule proteins, butyrophilin (8u) and xanthine oxidase (XO), as well as the small GTP-binding protein ARF, also were present. This lipoprotein complex was abundant in cytosol from lactating but not …
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The effects of Low α-Linolenic fatty acid Soybean Oil and Mid Oleic acid Soybean Oil on the growth of Her-2/neu and Fatty acid synthase over-expressing human breast cancer (SK-Br3) cells
… Some of the modified SOs contain altered fatty acid (FA) composition by selective breeding methods. Currently, low α- linolenic acid soybean oil (LLSO) and low α- linolenic acid and mid oleic acid soybean oil (LLMOSO) are available FA modified SOs in the market. The consumption of FA …
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Modular pathway engineering of microbial fatty acid metabolism for the synthesis of branched acids, alcohols, and alkanes
… Here we report the engineering of microbial fatty acid synthesis to provide both CoA-dependent and fatty acid synthase platforms for previously undescribed routes to medium-chain length, branched acids. Specifically we produced six-carbon 4-methyl-valeric acid via a CoA-dependent route and …
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Effects of acute and chronic exercise on the activities of hepatic lipogenic enzymes in rats
… citrate lyase (CL), pyruvate kinase (PK), and fatty acid synthase (FAS) activities were greater in rats fed a high-fructose diet than in rats fed high-glucose or high-cornstarch diets. Exercise decreased CL, PK, FAS, and glucose-6-phosphate dehydrogenase (G6PDH) activities, especially in …
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Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
… and function, the contribution of de novo fatty acid and phospholipid synthesis has not been elucidated. The data in this dissertation demonstrates the requirement of fatty acid synthesis for the generation and function of invadopodia. Inhibition of acetyl-CoA carboxylase (ACC), the …
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Understanding the physiological role of the small RNA RydC
… previously shown to stabilize cfa (cyclopropane fatty acid synthase) mRNA, resulting in higher levels of cyclopropane fatty acids in the cell membrane. Here, we show that additional sRNAs, ArrS and CpxQ, also directly regulate cfa post-transcriptionally. RydC and ArrS act through masking an RNase …
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Protein and Pathway Engineering for Biosynthesis or Aromatic Compounds
A type I fatty acid synthase, FAS-B from Brevibacterium ammoniagenes, and a type I polyketide synthase, 6-MSAS from Penicillium patulum, were successfully engineered via rational pathway design to synthesize TAL in vivo with a maximal yield of 1.7 g/L. The direct biosynthesis of phloroglucinol from …
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Validation and Application of a Novel Target-Based Whole-Cell Screen to Identify Antifungal Compounds
… fungal infections.</p> <p>Both the fungal fatty acid synthase and desaturase have been established as essential for fungal growth, virulence in a systemic infection, and are structurally distinct from their mammalian counterparts. However, there has been little success in developing …
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Studies of Genetic and Epigenetic Determinants of Prostate Cancer
… possesses tumor suppressor activity by targeting Fatty Acid Synthase. Overall, this dissertation provides further insights for the understanding of the mechanisms which underlie PCa initiation and progression.
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Pathway optimization and engineering for biofuel production
… pathway using a heterologously expressed fatty acid synthase coupled with a wax ester synthase. In this reaction, the esterification of a fatty acyl-CoA and fatty alcohol catalyzed by the wax ester synthase produces free fatty acid ethyl esters, otherwise known as biodiesel. Only initial …
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A randomised controlled trial of a diet and physical activity intervention in prostate cancer patients and related studies.
… determine if expression of the lipogenic enzyme Fatty Acid Synthase (FAS) differs in prostate cancer tissue compared with normal prostate tissue, and if FAS expression in cancer tissue has a role in prostate cancer progression. The number of studies in the area was limited, however 6 of the 7 …
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Combinatorial biosynthetic pathway engineering for microbial production of biofuels
… was investigated, using a heterologous fatty acid synthesis pathway, which would provide a completely orthologous route for biodiesel production. In this strategy, the endogenous fatty acid flux would not be redirected from cellular metabolism. Through heterologous expression of a Type-I …
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Characterization of a fatty acid elongase condensing enzyme by site-directed mutagenesis and biochemical analysis
Fatty acid elongation is the extension of de novo synthesized fatty acids through a series of four reactions analogous to those of fatty acid synthase. ELOs catalyze the first reaction in the elongation pathway through the condensation of an acyl group with a two carbon unit derived from …
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NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… phenocopied the effects of Nampt blockade on fatty acid synthesis thereby suggesting that Nampt maintains lipogenesis through sirtuin-dependent mechanisms. Additionally, we made the novel observation that Nampt inhibition causes endoplasmic reticulum (ER) stress in tumor cells and activates …
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Effect of Morinda citrifolia (Noni)-Enriched Diet on Hepatic Heat Shock Protein and Lipid Metabolism-Related Genes in Heat Stressed Broiler Chickens
… HSP70, HSP90, as well as key lipogenic proteins fatty acid synthase (FASN), acetyl co-A carboxylase alpha (ACCα), and ATP citrate lyase (ACLY). HS down-regulated the hepatic expression of lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (LIPC), but up-regulated adipose triglyceride …
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