Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Fast spiking interneurons"”.
-
The role of fast-spiking interneurons in cortical map plasticity
… which I have tested in this thesis. I focused on fast-spiking (FS) interneurons, which are thought to play an important role in<br/>adult cortical plasticity. I made electrophysiological recordings in layer 2/3 to determine how inhibitory circuitry in deprived cortex is affected by whisker …
-
Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus
… behaving mice. By rhythmically stimulating fast-spiking interneurons in somatosensory cortex, I can emulate the activity patterns that define gamma oscillations under natural conditions. Emulating gamma enhances the detection of threshold-level vibrissae deflections, analogous to the …
-
Large-scale neural recordings and biophysical models for inferring network mechanisms of ketamine anesthesia
… neural activity. Furthermore, I demonstrate that spiking UP-states that underlie gamma bursts wax and wane in a synchronous fashion across the majority of the neocortex, entraining local field potentials in the intralaminar thalamus, a major subcortical regulator of arousal. While cortical gamma …
-
Pitx3Null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses to l-DOPA and D1 Agonism and Lack Baseline Striatonigral Spiking
… (SPN) spike rates, SPNs <em>should </em>increase spiking during the motor response to l-DOPA. In fact, stimulating specific subsets of these neurons to spike in freely-moving wild type and parkinsonian animals causes or inhibits motor activity as predicted. However, pharmacological effects of DA …
-
Systematic examination of the impact of pre-stimulus alpha- mu and gamma band oscillations on perception : correlative and causal manipulation in mouse and human
… stimulus. Then using optogenetic control of the fast-spiking interneurons, we causally entrain a gamma oscillation to show enhancement of perception.
-
Striatal Microcircuits Underlying Control of Actions
… as a behavioral variable, but it is unclear how fast the animal moved, in what direction, or what effectors were used. The following experiments were designed to investigate the role of striatal neurons in controlling movement velocity in mice. The first set of experiments (Chapter 2) examined …