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Showing 1 to 20 of 22 for “"Fas Ligand"”.

  1. Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells

    Bradley, Michael JosephVirginia Tech1997

    … cytotoxicity, one perforin based and the other Fas ligand (FasL) based, have been characterized recently. It has also been shown that CD44, an adhesion molecule, can participate in signaling cytotoxic activity of cytotoxic T lymphocytes (CTLs). In the current study we tested the hypothesis that …

    vt Repository record

  2. Doppelt negative T-Lymphozyten, löslicher FAS Rezeptor und löslicher FAS Ligand bei Kindern mit häufigen Infektionen

    Renner, ChristianLudwig-Maximilians-Universität

    … wurden die Plasmaspiegel der Plasmaproteine sFas und sFasL. Der prozentuale Anteil an DN-T-Zellen lag signifikant über dem der gesunden Kontrollen bei gleichzeitig erniedrigten CD8 positiven Zellen. Es wird angenommen, dass aktivierte T-Lymphozyten über die Zwischenstufe der DN-T-Lymphozyten …

    lmu-germany Repository record

  3. Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor

    O'Callaghan, GraceUniversity College Cork2013

    … the anti-tumour immune response. Upregulation of Fas Ligand (FasL/CD95L) expression may represent one such mechanism. FasL is a member of the tumour necrosis factor superfamily that triggers apoptotic cell death following ligation to its receptor Fas. Numerous studies have demonstrated upregulated …

    cork Repository record

  4. Tumor cell-immune cell interaction: A lethal two way street

    Zeytun, AhmetVirginia Tech1999

    We investigated the role of Fas ligand in the development of anti-tumor immunity. The LSA tumor specific cytotoxic T lymphocyte (CTL) clone, PE-9, expressed both Fas and Fas ligand. This CTL clone upregulated Fas and Fas ligand expression upon activation through the T-cell receptor and induced …

    vt Repository record

  5. Apoptosis as a Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Immunotoxicity

    Kamath, Arati B.Virginia Tech1998

    … triggers apoptosis in the thymocytes and whether Fas and Fas ligand play a role in TCDD-mediated immunotoxicity. Administration of a single dose of TCDD at 0.1, 1, 5 or 50 mg/kg body weight intraperitoneally into C57BL/6 +/+ mice caused a significant dose-dependent decrease in the thymic …

    vt Repository record

  6. Experimentelle Untersuchungen zur Interaktion von Fas mit seinem Liganden an normalen und neoplastischen Zellen des lympho-hämatopoetischen Systems

    Richter, Manfred

    Fas-Ligand (FasL) stellt einen der 2 Effektormechanismen dar, mit dem T-Zellen den programmierten Zelltod induzieren. Die FasL-Expression auf Tumorzellen wurde in letzter Zeit als ein möglicher Mechanismus angesehen, mit dem sich Tumorzellen der Immunantwort des Körpers entziehen. Die Datenlage …

    freiburg-diss Repository record

  7. Molekulare Mechanismen des Tumorzelltodes induziert durch die Suizidgene Thymidinkinase und Purinnukleosidphosphorylase

    Krohne, Tim U.

    … verursachte eine Hochregulation von Fas in p53-positiven HepG2-Zellen und von Fas-Ligand (FasL) in beiden HCC-Zellinien. Diese Resultate demonstrieren zellinienspezifische Unterschiede in der Reaktion auf die Behandlung mit PNP/Fludarabin beziehungsweise TK/GCV und deuten darauf hin, …

    freiburg-diss Repository record

  8. JNK regulates Fas receptor mediated apoptosis in prostate cancer cell lines

    Curtin, JamesUniversity College Cork2003

    … elevated resistance to many cytotoxic drugs. The Fas receptor is a membrane bound protein capable of binding to a ligand called Fas ligand. Engagement of Fas receptor with Fas ligand results in clustering of Fas receptor on the plasma membrane of cells. A number of proteins responsible for …

    cork Repository record

  9. Cell-surface Tumoricidal Molecules and NF-kB in the Tumor-burdened Host

    McConnell, Michael JamesVirginia Tech2002

    … Additionally, I analyzed the expression of Fas and FasL on freshly isolated and LPS-stimulated macrophages and found no differences between TBH and NH macrophages. Fas and Fas ligand (FasL) cell-surface expression was analyzed on NH and TBH T-cells. While no difference was observed in …

    vt Repository record

  10. Molecular mechanisms mediating the induction of apoptosis by chemopreventive selenium compounds

    Ghose, AurnabUniversity of Glasgow2001

    … this was associated with a strong induction of Fas ligand (Fasl). Blocking Fas activation resulted in inhibition of apoptosis. Activities of stress kinases INK (c-jun N-terminal kinase) and p38 were also induced on selenium treatment and intervention studies using specific chemical inhibitors …

    glasgow Repository record

  11. Untersuchungen zu den Mechanismen in der Entwicklung maligner B-Zell-Lymphome vom mukosa-assoziierten lymphatischen Gewebe (MALT)-Typ

    Knörr, Constanze HelgaUniversität Würzburg

    … essentiellen Moleküle wie CD40-Ligand und Fas-Ligand exprimierten. Zudem konnten im Tumorgewebe vor allem TH2/3-Typ Cytokine (IL10, IL13, TGFb1) nachgewiesen werden, die ebenfalls das Tumorwachstum in vitro positiv beeinflussen können. Um in Zukunft spezifischere Untersuchungen …

    wurz-thes Repository record

  12. Quantitative analysis of cell decision processes in response to inflammatory cues and their role in mediating genotoxicity in hepatocytes

    Buck, Lorenna DianneMassachusetts Institute of Technology2012

    … a larger cell population. Using TNF-alpha, Fas ligand and, IL-6 cytokines in conjunction with oxygen and matrix cues, we investigated how extracellular stimuli influence cell fate in a pseudo-inflammatory environment and demonstrated that partial execution of apoptosis is a possible …

    mit Repository record

  13. The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip

    Bindal, Krithi R2012

    … histone deacetylase inhibitor, MS-275, on the Fas signaling pathway and susceptibility of osteosarcoma (OS) to Fas ligand (FasL)-induced cell death. OS metastasizes almost exclusively to the lungs. We have shown that Fas expression in OS cells is inversely correlated with their metastatic …

    uthsc Repository record

  14. A comparison of gene expression in tolerated and rejected islet grafts by gene microarray analysis

    Berg, Tobias

    … cytotoxicity-related genes (e.g., granzyme B and Fas ligand) were highly expressed. Also in the rejected grafts, a number of cytokines and chemokines and their receptors (e.g., IL-1b, IFN-g, MIG, RANTES) were found at high levels. The differential expression of selected genes found by microarray …

    freiburg-diss Repository record

  15. Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture

    Middlebrook, Aaron J.The University of Arizona.2004

    … populations of cells also expressed CD69, CD95 (FAS) and elevated levels of recombinase activating genes (RAG). This phenotype reflects the fact that these cells have received a positive selection signal, are for apoptosis and are likely attempting secondary TCR rearrangements. Nicotine effects …

    arizona-thes Repository record

  16. Circulating progenitor cells in atrial fibrillation: Relationship to endothelial dysfunction, thrombogenesis and inflammation

    Watson, Timothy J.University of Birmingham2011

    … Growth Factor, VEGF), apoptosis (soluble Fas/Fas ligand, sFas/sFasL) and inflammation (C-reactive protein, CRP; Interleukin-6, IL-6) in AF with particular reference to circulating progenitor cells (CPCs) as a novel marker of endothelial health/angiogenesis. Additionally the impact of …

    birmingham Repository record

  17. Effect of homozygous lpr and gld mutations on the immune functions and induction of autoimmunity

    Hammond-McKibben, Denise M.Virginia Tech1995

    … <i>lpr</i> gene encodes for an aberrant form of Fas (CD95), a molecule involved in apoptosis. The mouse <i>gld</i> gene leads to the expression of a defective Fasligand. Mice homozygous for <i>lpr</i> or <i>gld</i> mutations develop severe lymphoproliferative and autoimmune disease characterized …

    vt Repository record

  18. IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells

    Molgora, MartinaThe Open University2018

    … viral infected or tumor cells, which express ligands interacting with activating NK cell receptors. The expression of IL1R8 in NK cells prompted us to analyze its potential role in controlling NK cell effector functions.<br></br><br></br>Expression analysis showed that IL-1R8 was acquired …

    the-open-u Repository record

  19. Redox Regulation of T cell Activation and Function During Viral Infection

    Michalek, RyanWake Forest University2009

    … from PrdxII deficient mice were resistant to Fas-Ligand induced apoptosis, but susceptible to death-induced by TCR crosslinking. During acute viral infection, the number of effector CD8+ T cells in PrdxII-/- mice was increased, while memory cells were similar to wild-type mice. Following …

    wfu Repository record

  20. Characterisation of the role of Fas in intestinal inflammation and cancer

    Fernandes, PhilanaUniversity College Cork2015

    Background: The role of Fas (CD95) and its ligand, Fas ligand (FasL/CD95L), is poorly understood in the intestine. Whilst Fas is best studies in terms of its function in apoptosis, recent studies suggest that Fas ligation may mediate additional, non-apoptotic functions such as inflammation. Toll …

    cork Repository record

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