Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Farnesol"”.
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Investigating the protective effects of farnesol formations against neuroinflammation
<p>Farnesol (FOL) is a naturally-produced 15-carbon organic acyclic sesquiterpene alcohol (isoprenol) that acts as a potent blocker of neuronal voltage-gated Ca2+ channels (L- and N-type) and is found in the human brain. FOL has potent anti-oxidant and antiinflammatory effects in vitro and is …
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Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells
… (TGs) in liver. The endogenous isoprenoid farnesol reduces hepatic TG levels in rodents, and this effect appears to involve at least two nuclear receptors, peroxisome proliferator-activated receptor α and farnesoid X receptor (FXR). However, farnesol’s effects on human hepatic lipid …
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Chemical Control and Understanding of Horizontal Gene Transfers, Drug-Resistance Development, and Filament and Biofilm Formation
… horizontal gene transfer are studied. Saturated farnesol derivatives show inhibition effect on tetracycline-enhanced plasmid transformation, ciprofloxacin-enhances PAPI-1 transduction, and PAPI-1 conjugation. Further study of ciprofloxacin-resistance development in P. aeruginosa is conducted by …
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The Effects of Quorum Sensing Molecules on Streptococcus mutans Biofilm
… QQ molecules (p-coumaric acid, tyrosol, and farnesol) on S. mutans biofilm formation on biotic and abiotic surfaces. This research specifically studied the changes in eDNA, protein, carbohydrate, and viable cells in the extracellular matrix (ECM) of the biofilm. The gene expression of gtfb …
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Effects of Quorum Quenchers on Aspergillus fumigatus Conidia Aggregation, Adhesion to Surfaces, and Biofilm Formation
… effects of microbial quorum quenchers, furanone, farnesol and tyrosol were investigated against A. fumigatus for the first time. Amphotericin B (AMB), a common antifungal agent used against A. fumigatus infection, carries adverse effects against human health. So, triclosan’s antifungal effect in …
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Studies on the Stereochemistry and Mechanism of Taxadiene Biosynthesis
… Methoxy-substituted nor analogs of geraniol, farnesol, and geranylgeraniol were prepared by alkylation of carbanions generated from allylic ethers.
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Investigation of the effects of Elicitation and Quorum sensing on Monascus purpureus C322
… (MO) and quorum sensing molecules (farnesol, tyrosol, butyrolactone-I, linoleic acid) in M. purpureus C322. Fermentation processes were conducted in shaken flasks and scaled up to 2.5 L stirred tank bioreactors. Supplementation with elicitors and QSMs notably increased pigment and …
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Investigating Physical and Chemical Interaction of Aspergillus terreus Spores for Changes in Morphology and Physiology
… sensing molecules butyrolactone I, tyrosol and farnesol, alongside other chemicals expressed in literature as having potential effects on the physiology and morphology of a microbial culture. Furthermore, supplements from Aspergillus terreus MUCL 38669 obtained from I) spore supernatant, II) …
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Investigating the protective effects of intestinal GABA[subscript A] receptor activation on an animal model of Multiple Sclerosis
… a positive allosteric GABAA receptor modulator, farnesol, ameliorates the progression of experimental autoimmune encephalomyelitis (EAE), a murine model of MS and whether those effects correlated with a decrease in immune cell infiltration of the central nervous system. We observed a significant …
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A New Class of Antibiotic That Prevents Drug Tolerance, Persistence, and Resistance By Controlling Emergence of Phenotypes.
… factor of P. aeruginosa. Here, we showed Farnesol as adjuvant molecule with silver therapy against P. aeruginosa and S. aureus. Farnesol eradicates resistance against silver by inhibition of pyocyanin. Farnesol also potentiated silver against dual biofilms of P. aeruginosa and S. …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
… proteins, respectively, while alkynyl-farnesol allowed more robust analysis of S-prenylated proteins. These new lipid chemical reporters enabled the discovery of bacterial virulence factors that are lipidmodified by host enzymes during infection as well as lipidated host proteins …
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Towards a more efficacious treatment for Oropharyngeal Candidiasis (OPC): Hydrogel-forming tablets for the controlled release delivery of Chlorhexidine diacetate
… do not develop resistance against it. Thymol and farnesol were also tested individually and in combination with CHD to investigate a synergistic effect against Candida planktonic cells. The effects of CHD and thymol were investigated against C. albicans biofilm after two hours exposure by testing …
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Mechanisms of Volatile Odorant Detection and Corresponding Behavioral Effects in Drosophila
… sesquiterpene found in citrus fruit peel called farnesol (FOH). Furthermore, FOH detection by Or83c instructs oviposition preference in Drosophila via ai2a sensory neurons. These studies advance general knowledge of the architecture and complexity of the Drosophila olfactory system and provide …
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An Assessment of Perceived Crop Damage in a Tanzanian Village Impacted by Human-Elephant Conflict and an Investigation of Deterrent Properties of African Elephant (Loxodonta Africana) Exudates Using Bioassays
… at Ndarakwai Ranch in northern Tanzania, (E,E)-farnesol and 3-pentanone were bioassayed with wild African elephants. The compounds tested did not elicit bioactivity, but the importance of continued research on biologically meaningful signals is essential to effectively reducing HEC.
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Mechanisms of bacterial polyprenyl transferases and multi-target drug discovery for tuberculosis
… as a phosphatase. Using DSC, we confirmed that farnesol shift and broaden the gel-to-liquid crystal transition of lipids. The X-ray structure of the bacterial diterpene cyclase ent-kaur-16-ene synthase from the soil bacterium Bradyrhizobium japonicum was determined in apo-, substrate and …
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In situ Metabolism and Biogeography of Phototrophic Consortia
… bacterial epibionts, and their d13C measured. Farnesol, tetradecanol, hexadecanol and hexadecenol all were significantly enriched in 13C compared to bulk dissolved and particulate organic carbon, and compared to the biomarkers of purple sulfur bacteria. The difference (Dd13C) between d13C …
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Targeting isoprenoid and quinone biosynthesis for antimicrobial discovery
… growth was partially ""rescued"" by addition of farnesol or overexpression of FPPS; and there was synergistic activity with known isoprenoid biosynthesis pathway inhibitors. In bacteria, farnesyl diphosphate (FPP) is further utilized in downstream isoprenoid biosynthesis pathway to synthesize …
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Stimulation of Western Australian Sandalwood (Santalum spicatum) oil production using multiple treatments [thesis]
… as the oil constituents α-santalol, β-santalol, farnesol, nuciferol, and β-bisabalol oil compositions (percentage) and yield (%w/w). All trees that were harvested ii were cut into 8 discs measuring 25 mm each, and the percentage of heartwood area at each height was measured and recorded. All data …
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Natural and Synthetic Ligand-Binding Induce Different Pilin Assemblies in vitro and Control P. aeruginosa Bioactivities in vivo, and Development of Bacterial-Motility Enabled Binding Assays
… class of synthetic ligands consists of saturated farnesol tethered with disaccharide also binds directly to pilin proteins at picomolar range by intrinsic fluorescence, and to dominate rhamnolipids resulting in complete inhibition of swarming motilities, and to induce the pilin proteins to form an …
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