Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Farnesoid X receptor (FXR)"”.
-
Gene selective regulation by hepatic Farnesoid x receptor (fxr) in health and disease
… of metabolites contributes to metabolic disease. Farnesoid X Receptor (FXR) which is known as a primary bile acid nuclear receptor plays important roles for maintaining levels of metabolites like triglycerides, fatty acids and glucose by regulating its targets genes in liver. Over the past …
-
Elucidating the Molecular Mechanisms Underlying the Hepatic Farnesoid X Receptor (FXR)-mediated Effects that Contribute to the Triglyceride-Lowering Ability of a Grape Seed Proceyanidin Extract
… levels via activation of the nuclear hormone receptor, farnesoid x receptor (FXR), thereby increasing small heterodimer partner (SHP) messenger ribonucleic acid (mRNA) expression, which then inhibits transcription of Sterol Regulatory Element Binding Protein 1c (SREBP-1c), a key transcription …
-
Účinek agonistů nukleárních receptorů (FXR, CAR, aj.) na játra a hepatocyty za různých stavů
Effects of nuclear receptor agonists (e.g., FXR, CAR) on the liver and hepatocytes in vivo and in vitro across diverse physiological and pathological conditions Metabolic dysfunction-associated steatotic liver disease (MASLD) affects a substantial proportion of the global population, while …
-
Uncovering a novel role for FXR-SHP axis in liver physiology, diseases and beyond
… mechanisms that the liver utilizes is nuclear receptor signaling, which in turn can transcriptionally regulate gene networks. My doctoral thesis focuses on studying the role of two nuclear receptors, FXR and SHP in maintaining liver function. Farnesoid X Receptor (FXR) and Small Heterodimer …
-
Nuclear receptor co-repressor actions in bladder cancer
Nuclear receptors (NR) are ligand dependent transcription factors. In the current study, expression of VDR and Farnesoid-X-receptor (FXR) protein is demonstrated along with relative mRNA expression of a range NRs and co-repressors in four bladder cancer cell lines. Nuclear co-repressor 1 (NCoR1) is …
-
The development of a mouse model of post-bariatric hyperinsulinemic hypoglycemia
… metabolite levels. Mice were treated with the Farnesoid X Receptor (FXR) agonist, fexaramine (Fex), or vehicle for 5 days before undergoing a glucose tolerance test (GTT). Mice were sacrificed with tissues collected immediately thereafter. PCR was performed to quantify expression of FXR target …
-
Developing novel prophylactic approaches against SARS-CoV-2 infection
… into cells through the modulation of viral host receptors, such as ACE2, could represent a new chemoprophylactic and therapeutic approach for COVID- 19 complementing vaccination. However, the mechanisms controlling ACE2 expression remain elusive, partly due to low ACE2 levels in experimental …
-
Bile Acids and Nuclear Receptors: Their Roles in Nutrition and Cancer
The bile acid receptor, also known as farnesoid X receptor (FXR), is essential for feedback regulation of bile acid synthesis. Bile acids are required for the proper absorption of dietary lipids, including fat-soluble vitamins; however, some bacterial metabolites of bile acids have been shown to …
-
THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
Farnesoid X receptor (FXR) is a ligand activated transcription factor belonging to the nuclear receptor superfamily and bile acids are its endogenous ligands. FXR is a critical regulator of the enterohepatic circulation of bile acids, lipid homeostasis, glucose metabolism, and tumor suppression in …
-
Follow your gut: Does AKR1D1 impact gastrointestinal health?
… load was increased in AKR1D1 KO mice. Toll-like receptor 4 (TLR4) signalling was upregulated in the female mice, as was the pan-macrophage marker, F4/80, at mRNA and protein level. Suggestive of impaired barrier function, intestinal morphology of the AKR1D1 KO mice was modified, key ileal and …
-
The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
… fatty liver disease (NAFLD). Bile acid receptor Farnesoid X receptor (FXR) agonists have been shown to ameliorate steatosis and liver damage and improve insulin resistance in NASH patients but also cause adverse effects including gastrointestinal disturbances, hypercholesterolemia and …
-
The roles of orphan nuclear receptors, SHP and FXR, and their cofactors in bile acid signaling
… understood. In recent years, two orphan nuclear receptors, farnesoid X receptor (FXR) and small heterodimer partner (SHP), have been identified as key regulators in bile acid signaling. FXR was revealed as the first in vivo bile acid biosensor and was shown to regulate cholesterol/bile acid …
-
Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells
… effect appears to involve at least two nuclear receptors, peroxisome proliferator-activated receptor α and farnesoid X receptor (FXR). However, farnesol’s effects on human hepatic lipid metabolism are currently unknown. The objective of this study is to evaluate how farnesol treatment would …
-
Age-Associated Hepatic Drug Transporter Expression and Its Implications for Pediatric Pharmacotherapyflexibility affect DNA topoisomerase I function
… also characterized the ontogeny of four nuclear receptors through measurement of their gene expression. Nuclear receptors belong to a highly conserved gene superfamily of transcriptional factors that regulate the expression of their target genes, many of which include members of the ABC …
-
Role of Src phosphorylation of FXR in bile acid regulation
… these levels must be tightly regulated. The farnesoid X receptor (FXR) is the primary bile acid nuclear receptor and acts as the master regulator of bile acid homeostasis, preventing liver damage caused by bile acid accumulation. FXR does this by regulating the expression of many target genes …
-
Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
… Partner (SHP, NR0B2), a member of the nuclear receptor superfamily, is an orphan receptor that lacks a DNA binding domain but contains a putative ligand binding domain. SHP forms non-functional heterodimers with DNA binding transcriptional factors and, thereby, functions as a transcriptional …
-
Effects of diet and loss of ovarian hormone production on adiposity, inflammation, cecal integrity, and gut microbial communities of rodent models
… hormone production. Lower cecal expression of farnesoid X receptor (FXR) and fibroblast growth factor (FGF15) was observed in the OVX mice compared to SHM, suggesting an interaction between estrogen and the FXR-FGF15 pathway that is known to affect bile acid synthesis. PCoA of weighted and …
-
Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… thesis studies, I explored the function role of Farnesoid X receptor (FXR) and microRNA-34 (miR-34a), as key transcriptional and post-transcriptional regulators respectively, in maintaining metabolic hemostasis and energy balance. Nuclear receptors (NRs) are lipophilic ligand-dependent …
-
Characterization of intestinal small heterodimer partner and farnesoid X receptor in bile acid and lipid metabolism
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01