Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 147 for “"Farmacologia"”.
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Design and synthesis of small molecules for oncological and neurodegenerative diseases with multitarget properties [Progettazione e sintesi di piccole molecole con proprietà multitarget per malattie oncologiche e neurodegenerative]
… multi-target possa superare i limiti della farmacologia tradizionale a singolo bersaglio.
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Pharmacological targets for treatment of retinal neurodegenerations: new perspectives [Nuove prospettive sui target farmacologici per il trattamento della neurodegenerazione retinica]
… emerso come una nuova strategia nel campo della farmacologia oculare. In particolare, questo metodo si è rivelato utile per identificare nuovi target farmacologici, comprendere l’eziologia di malattie complesse e il meccanismo d'azione di nuovi farmaci. Infatti, attraverso l'applicazione della …
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Development of screening assays to test novel integrin antagonists in allergic inflammation
Aim of the research: to develop a prototype of homogeneous high-throughput screening (HTS) for identification of novel integrin antagonists for the treatment of ocular allergy and to better understand the mechanisms of action of integrin-mediated levocabastine antiallergic action. Results: This …
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L'infiammazione intestinale nell'animale sperimentale come modello per lo sviluppo di nuovi farmaci: ruolo della via tachichininergica nelle malattie infiammatorie intestinali
Background: Several lines of evidence showed that inflammation is associated with changes in the expression of tachykinins both in human and animal models. Tachykinins, including substance P (SP), are small peptides expressed in the extrinsic primary afferent nerve fibres and enteric neurons of the …
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Isotiocianati come potenziali farmaci antileucemici: identificazione in vitro ed ex vivo del profilo molecolare e cellulare
Il presente studio ha come obbiettivo lo sviluppo di composti di origine naturale come potenziali farmaci antitumorali, attraverso la definizione dei loro specifici target cellulari e molecolari su diversi modelli cellulari ad alta predittività. Gli isotiocianati, contenuti nei vegetali …
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Expression of the repressor element-1 silencing transcription factor (REST) is regulated by IGF-I and PKC in human neuroblastoma cells
The repressor element 1-silencing transcription factor (REST) was first identified as a protein that binds to a 21-bp DNA sequence element (known as repressor element 1 (RE1)) resulting in transcriptional repression of the neural-specific genes [Chong et al., 1995; Schoenherr and Anderson, 1995]. …
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Inibizione selettiva del gene MYCN mediante PNA (acidi peptido nucleici) anti-gene nel rabdomiosarcoma umano
MYCN oncogene amplification/expression is a feature of many childhood tumors, and some adult tumors, and it is associated with poor prognosis. While MYC expression is ubiquitary, MYCN has a restricted expression after birth and it is an ideal target for an effective therapy. PNAs belong to the …
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Transcriptional regulation of human mu-opioid receptor gene: functional characterization of activating and inhibitory transcription factors
The organization of the nervous and immune systems is characterized by obvious differences and striking parallels. Both systems need to relay information across very short and very long distances. The nervous system communicates over both long and short ranges primarily by means of more or less …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
Nandrolone and other anabolic androgenic steroids (AAS) at elevated concentration can alter the expression and function of neurotransmitter systems and contribute to neuronal cell death. This effect can explain the behavioural changes, drug dependence and neuro degeneration observed in steroid …
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Indagine sul coinvolgimento del sistema neuropeptidergico nocicettina/recettore NOP a carico della trasmissione nocicettiva
Oggetto di studio in questa tesi è stato il ruolo modulatorio svolto dal neuropeptide nocicettina/orfanina FQ a carico della trasmissione nocicettiva. A scopo introduttivo, sono state illustrate le conoscenze attuali sul sistema nocicettina-NOP; sono state descritte le funzioni, la struttura e la …
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LONG-LASTING MOLECULAR ALTERATIONS FOLLOWING EARLY LIFE STRESS IN RATS: ROLE OF GUT MICROBIOTA AND INFLAMMATION
It is well known that stress, especially when experienced early in life, affects the brain developmental trajectories leading to an enhanced vulnerability for several mental disorders later in life. The adverse outcomes depend on the timing of the stressful experiences, and in this contest, early …
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Towards precision medicine in psychiatry: investigating the contribution of cellular aging, pleiotropy and gender differences in psychiatric disorders and pharmacological response
Severe mental disorders such as bipolar disorder (BD), schizophrenia (SZ) and major depressive disorder (MDD) are characterized by a substantial socio-economic burden. Pharmacological treatment is the mainstay in the acute phase of severe mental disorders as well as in the prevention of …
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