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Showing 1 to 4 of 4 for “"Fanconi Anemia pathway"”.
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Structural and Biochemical Investigation of Fanconi Anemia Pathway Activation
… repair them results in a severe genetic disease, Fanconi Anemia (FA), manifested by developmental impairment, bone marrow failure, and predisposition to various types of cancers. In healthy cells, a specialized cascade of DNA repair proteins comes together to establish the FA pathway that …
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The Fanconi anemia pathway and HELQ work alongside dormant replication origins to suppress replication-associated genome instability
… cells also displayed intrinsic activation of the Fanconi anemia (FA) pathway, suggesting that it too plays a functional role in fork progression. Indeed, disruption of FA pathway activation in the <italic>Mcm4<super>chaos3/chaos3</super></italic> background led to an even higher number of …
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Development of The Ark Assay For Quantitating Dna- Protein Crosslink Accumulation and Fanconi Anemia Pathway Involvement In The Repair Process
… DPC accumulation. Functionally, we observe that Fanconi anemia pathway-inactivated cells incur increased DPC accumulation and delayed repair, suggesting a role for the Fanconi anemia pathway in the processing of these deleterious lesions.</p>
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… partner of FANCI/FANCD2 (ID2) complex of the Fanconi anemia pathway. Using cells isolated from human KIN patients and Fan1-deficient mice, we showed that ICL repair function of FAN1 is non-overlapping with Fanconi anemia proteins, yet redundant with SNM1A, an exonuclease that was previously …