Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Factor Xa"”.
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Designing Direct and Indirect Factor Xa Inhibitors
… lines of evidence support the superiority of factor Xa (FXa) as a promising target to develop novel anticoagulants. This work focuses on the design of direct and indirect FXa inhibitors using an interdisciplinary approach. As indirect FXa inhibitors, a focused library of tetrasulfated …
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Design and synthesis of novel factor Xa inhibitors.
Design and synthesis of novel factor Xa inhibitors.
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Antithrombotic agents under flow conditions
… UFH, which has equal anti-factor Xa and anti-thrombin activity, was able to inhibit TG under static and flow conditions. On an anti-Xa unit basis, comparatively more LMWH (with a 10: 1 ratio of anti-factor Xa to anti-thrombin activity) was required to inhibit TG under static …
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Integrating LLMs and Causal Inference: Comparing Oral Anticoagulant Effects on Thrombosis Recurrence, Bleeding Risk and Death Using MIMIC-IV Data
… (VKA) which was primarily Warfarin, and Factor Xa inhibitors (Apixaban, Edoxaban, Rivaroxaban) were estimated with targeted maximum likelihood estimation (TMLE), which uses initial Super Learner fits for the outcome and treatment mechanisms followed by a targeting step that achieves …
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Choline Inhibition of Prothrombinase
… of choline on prothrombinase activity, bovine factor V and human factor II were isolated in this laboratory by established methods, and other prothrombinase components were obtained from commercial sources. The activity of venom-activated bovine factor Xa was assayed in the presence of factors …
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Use of the cellulose-binding domain of a cellulase from cellulomonas fimi for affinity purification of fusion preteins
… removed by specific proteolytic cleavage with Factor Xa or by a C. fimi serine protease. CBD fusions with human interleukin 2 (IL2) were constructed, but are predominantly insoluble and extensively degraded on expression in E. coli. However, the fusion polypeptides can still be purified by …
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Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy
Recently it has been demonstrated that tissue factor (TF) plays an important role in the induction and/or progression of cardiac hypertrophy. The aim of this thesis was to examine the relationship between TF and the onset of cardiac hypertrophy. Cardiac hypertrophy was achieved by aortic …
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The tissue factor-factor VII(a) complex in blood coagulation
… cascade in vivo is mediated by tissue factor (TF), which functions as the cell surface receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation of factor VII (FVII) to FVIIa. Upon vascular injury, TF is exposed to the bloodstream where it …
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Studies of Coagulation and Fibrinolysis
… consisting of either human or bovine factor Va (FVa) was investigated. The difference was due to the species origin of the heavy chain. Because the conserved domains show high sequence homology, the carboxy-terminus was studied. The calculated pI of the ten carboxy-terminal residues …
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Novel Sulfated 4-Hydroxycinnamic Acid Oligomers as Potent Anticoagulants
… need for anticoagulation therapy. Thrombin and factor Xa have been prime targets for regulation of clotting through the direct and indirect mechanism of inhibition. This work investigates chemo-enzymatically prepared oligomers of 4-hydroxycinnamic acids (DHPs) as potential anticoagulants. …
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Engineering functional recombinant proteins based on antibody domains and fragments of C. botulinum neurotoxin
… by a protease such as EK (Enterokinase) or FXa (Factor Xa) at specific residues within the sequence. The contrast in molecule activation will distinguish the best candidates. It was decided that targeting the tyrosine kinase receptor family was most suited to this research because (i) there …
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Biochemical Evaluation of Lignin-like Molecules
… found to be direct inhibitors of thrombin and factor Xa, acting through a unique exosite-2 mediated process. To elucidate the structural basis of this mechanism, we studied unsulfated and size fractionated LMWLs. Detailed enzyme inhibition studies with sulfated and unsulfated LMWLs of ferulic …
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Bifunktionale Fusionsproteine : Kombination hochselektiver, direkter FXa Inhibition mit aktivationsspezifischer GP IIb/IIIa Blockade einerseits, und zielgerichtetem Fibrin-Targeting andereseits
… und einem potenten, direkten Faktor Xa Inhibitor herzustellen. <br> <br>Single-chain Antikörper sind über einen Linker zu einer "Kette" verbundene Immunglobulin-Derivate, die nur aus den variablen Regionen der schweren und leichten Kette bestehen. Das Tick Anticoagulant Peptide (TAP) …
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MOLECULAR MODELING STUDIES OF HEPARIN AND HEPARIN MIMETICS BINDING TO COAGULATION PROTEINS
… the antithrombin mediated inhibition of factor Xa and thrombin by a conformational activation mechansism and bridging mechanism, respectively. The sequence specific pentasaccharide DEFGH in full length heparin is the most important fragment for high affinity and activation of …
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Studies of structure-function relationships in two human coagulation proteins: factor XII and prothrombin
The epitope(s) of three anti human factor XII monoclonal antibodies were localized by screening a factor XII cDNA expression library in kgt11. One antibody, B7C9, had been shown previously to inhibit the activation of FXII by negatively charged surfaces. The positive recombinant phage contained …
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Discovery Of Inactive E* Conformations In Thrombin And Other Vitamin K- Dependent Clotting Proteases
… belonging to Vitamin K-dependent clotting factors is significantly affected by Na+ through an allosteric mechanism. Over the past 30 years, structural and biochemical studies revealed that Na+ enhances the enzymatic properties of these proteases from a low activity, E, to a high activity: …