Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Factor VII"”.
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The tissue factor-factor VII(a) complex in blood coagulation
… cascade in vivo is mediated by tissue factor (TF), which functions as the cell surface receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation of factor VII (FVII) to FVIIa. Upon vascular injury, TF is exposed to the bloodstream where it …
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INITIATION OF EXPERIMENTAL ACUTE PANCREATITIS AND MODULATION OF INFLAMMATORY RESPONSE
… The anti-coagulant active site-inhibited factor VII (fVIIai) was shown to drastically decrease the inflammatory response. The effects in reducing neutrophil infiltration differed substantially between different organs. Nuclear factor kappa B (NFκB) activation was also shown to be affected …
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Crosstalk between Inflammation and Coagulation in Acute Pancreatitis - Experimental and Clinical Studies.
… coagulation is known to exist, where coagulation factor VII (FVII) and tissue factor (TF) are considered to be pivotal players. In this thesis the crosstalk between inflammation and coagulation in acute pancreatitis (AP) has been investigated. The results from the first paper, where active site …
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Simulating atomic-level interactions in the coagulation cascade
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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The development of strategic planning concept process model for small medium enterprise (SME) in the construction industry
… were to identify and investigate the influencing factors and barriers that hinder strategic planning application in SME construction organisations. In satisfying this aim and objective, the research was undertaken in two distinct phases. In phase one, an exploratory study that utilised …
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… kallikrein mediates the conversion of factor XII (FXII) to activated factor XII (FXIIa) thereby potentiating the intrinsic pathway of coagulation. Thus, plasma kallikrein represents an important target for the development of novel anti-inflammatory and anti-thrombotic agents. The …
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Contribution of different types of phospholipids in blood coagulation
… on γ-carboxyglutamate-rich (GLA) domains of factor X (fX) and prothrombin as representative GLA domains of clotting factors, which have been the subject of several protein-phospholipid interaction studies. Based on the results of this project, we proposed a new mechanism for the binding of …
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Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease
… for 17 years. Conventional cardiovascular risk factors, C-reactive protein (CRP), interleukin-6 (IL-6), intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), E-selectin, fibrinogen, D-dimer, tissue plasminogen activator (t-PA), vonWillebrand factor (vWF), factor VII, …
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Effect of dietary fibre on selected haemostatic variables and C-reactive protein
… for CVD include, amongst others, the haemostatic factors tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor type 1 (PAI-1), factor VII (FVII) and fibrinogen and more recently, C-reactive protein (CRP), a sensitive marker of inflammation. Epidemiological studies have …