Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Factor V"”.
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Arterial Thrombosis in Factor V Leiden or Activated Protein C Resistance. Clinical and Experimental Studies.
… Activated protein C (APC) resistance due to Factor V Leiden mutation as the most prevalent genetic risk factor, yet known, for venous thromboembolism. This has been documented in 20-60% of patients with deep vein thrombosis (DVT). Whether such propensity also exists in arterial circulation is …
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Evaluation of Current Thrombophilia Screening Practices of Internists, Family Physicians, and Obstetricians/Gynecologists: Factor V Leiden Genetic Testing and Referral Patterns
<p>Thrombophilia is a complex, multifactorial condition in which the patient exhibits an increased susceptibility to form blood clots, especially in the veins of the lower extremities. A mutation in the gene encoding for factor V, known as factor V Leiden (FVL), is the most common cause of …
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Human ceruloplasmin gene and cDNA
… of ceruloplasmin sharehomology with the cDNAs of factors V and VIII of the blood coagulation cascade,suggesting that the three genes evolved from a common ancestral gene. Thereare two ceruloplasmin specific mRNA transcripts, 3.7 and 4.4 Kb, produced bythe liver. Expression of the gene is regulated …
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Characterization of OmpT: An outer membrane vesicle protease Escherichia coli that attenuates blood coagulation.
… significant mortality and morbidity globally. Factor V (Mr-330,00Da) is a procofactor that upon activation to FVa profoundly enhances thrombin generation and fibrin clot formation as part of prothrombinase. The fibrin clot immobolizes the pathogen and allows the immune system to target and …
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Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
… known membrane binding inhibitors of coagulation factor V and VIII C2 domains affect PI3Kα- membrane interactions; and how compounds predicted to occupy a newly discovered drug binding site affect activity and signaling of PI3K. To identify the contributions of different regions of the active site …
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Choline Inhibition of Prothrombinase
… of choline on prothrombinase activity, bovine factor V and human factor II were isolated in this laboratory by established methods, and other prothrombinase components were obtained from commercial sources. The activity of venom-activated bovine factor Xa was assayed in the presence of factors …
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NOVEL MONO-, BI- AND TRI-SPECIFIC IMMUNOMODULATORY ANTIBODIES FOR CANCER THERAPY AND TOOLS FOR OTHER THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
… the coagulation cascade, and in particular Factor V, was also generated by using phage display. The novel mAb, called D9, was found able to efficiently bind to Factor V in both its native and activated forms, with nanomolar KD values and to slow down the coagulation by prolonging the …
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Polyphosphate modulates hemostasis, thrombosis, and inflammation
… a particular emphasis on the contact pathway and factor V activation. A serious impediment to progress in studying polyP in biological systems is the dearth of techniques for manipulating polyP to investigate polyP-protein interactions. To this end, I developed a novel method for covalently …
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The Remediation of Students in Counseling Graduate Programs: Behavioral Indicators, Terminology, and Interventions
… and advanced counseling skills. Five factors were identified within the behavioral indicators based on which can be remediated: Factor I, Personal Competencies; Factor II, Professionalism; Factor III, Personal Challenges; Factor IV, Honesty; and Factor V, Clinical Competencies. …
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The regulation of blood coagulation by high-density lipoprotein particles
… were unable to support binding to activated factor V (FVa). Serum was also shown to neutralize the procoagulant effect of anionic liposomes with transfer of phospholipids to both low-density lipoprotein (LDL) and HDL particles. The transfer of phospholipids was dependent on a catalytically …
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Characterization of a secreted escherichia coli 086a:K61 protease that inactivates human coagulation FV
… diarrhea cases globally. Coagulation Factor (F) V circulates as an inactive procofactor (Mr 330kDa) which upon thrombin activation to the active cofactor, FVa, functions in prothombinase to accelerate prothrombin to thrombin conversion by 300,000-fold. The ability of E.coli O86a:K61 to …
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Use of geographic information systems for assessing ground water pollution potential by pesticides in central Thailand
… located in the western part of central Thailand. Factors used for this purpose were soil texture, percent slope, primary land use, well depth, and monthly variance of rainfall. These factors were reclassified to a common scale showing potential to cause groundwater contamination by pesticides. …
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VENOUS THROMBOEMBOLISM IN SOUTHERN SWEDEN EPIDEMIOLOGY AND RISK FACTORS
… is still insufficient information on VTE risk factors and patient characteristics in the general population. Previously published incidences of VTE (deep venous thrombosis [DVT] and pulmonary embolism [PE]) vary from 71 to 192 per 100,000 individuals per year. Incidences of DVT and PE have been …
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A framework to enhance organisational performance in large-scale, diverse infrastructure major projects
… A framework is devised to investigate what factors constrain or improve performance in a culturally complex environment. Performance in this sense includes its safety indicators, health and overall performance data (timing and cost) which are aims of business in the built environment, as …
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Towards an Integrated Model for the Judicial Regulation of State Contracts in South Africa
… of the other. This binary method uses five factors: (i) statutory source of power; (ii) superior or coercive powers of the state; (iii) duty to act in the public interest; (iv) public impact of the action; and (v) identity of the functionary as the state. That approach has proved to be …
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Επιπλοκές της κύησης σε γυναίκες ελληνικής καταγωγής με κληρονομική θρομβοφιλία
Σκοπός: Οι μορφές κληρονομικής θρομβοφιλίας έχουν θεωρηθεί σαν μία κατάσταση με πιθανά αυξημένη ευαισθησία για δυσμενή έκβαση της εγκυμοσύνης. Σκοπός της παρούσας μελέτης είναι η διερεύνηση της επίδρασης των κληρονομικών θρομβοφιλικών παραγόντων στην έκβαση της εγκυμοσύνης σε τυχαίο δείγμα εγκύων …
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Trombose da veia porta em crianças e adolescentes : deficiência das proteínas C, S e antitrombina e pesquisa das mutações fator V Leiden, G20210A da protrombina e C677T da metileno-tetraidrofolato redutase
Objetivo: A trombose da veia porta é uma causa importante de hiper-tensão porta em crianças e adolescentes, porém, em uma proporção importante dos casos, não apresenta fator etiológico definido. O objetivo desse estudo é determinar a freqüência de deficiência das proteínas inibidoras da coagulação …