Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"FZD5"”.
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Genome-wide CRISPR Screens to Uncover Novel Therapeutic Targets in Wnt-β-catenin Driven Gastrointestinal Cancers
… Frizzled receptor gene out of ten paralogs, FZD5, to be essential for the proliferation of each RNF43 mutant PDAC line. We generated a synthetic human monoclonal antibody specific to FZD5, and found it effective in reducing the growth of RNF43 mutant pancreatic cancers in vitro and in …
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Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer
… in <i>ARHGEF10L</i> and 0.75-fold decrease in <i>FZD5</i> expression upon PADI2 overexpression. In this thesis, The Cancer Genome Atlas expression studies of <i>PADI2</i> showed that higher <i>PADI2</i> confers decreased survival of EOC patients. Conversely, <i>PADI2</i> overexpression <i>in …