Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"FXR1P"”.
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Microrna-mediated regulation and the fragile X family of proteins
… fragile X mental retardation protein (FMRP) and FXR1P, are regulated by post-translational modifications and microRNAs (miRNAs), respectively. Both proteins play key roles in normal development and function. The absence of FMRP leads to the cognitive defects seen in Fragile X syndrome, the …
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Identification of Loss of Specific FMRP-RNA Interactions as a Cause of Fragile X Syndrome
… competent to bind both protein partners such as FXR1P and FXR2P and, via its RGG-domain, to G-quartet RNA, confirming it is not a completely functionless denatured protein. However, I304N protein is defective in RNA binding and is dissociated from polyribosomes. Moreover, electrophysiologic and …
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Modulation of Stress Granules formation: Role of mGlu5 receptor and FMRP and implications for pathophysiology of Fragile X Syndrome
… can interact with RNA-binding proteins such as FXR1P, FXR2P, NUFIP and 82-FIP, and with proteins that do not bind RNA, like CYFIP1 and CYFIP2. The interaction with these different proteins may modulate FMRP functions and its RNA affinity. A new role of FMRP in mRNA metabolism as component of …