Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"FXII"”.
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Studies of structure-function relationships in two human coagulation proteins: factor XII and prothrombin
… shown previously to inhibit the activation of FXII by negatively charged surfaces. The positive recombinant phage contained inserts that coded for the amino-terminal 31 amino acids of FXII. These results were confirmed by binding of B7C9 to synthetic peptides containing amino acids 1-28 and …
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A New Role for Beta-Amyloid in Alzheimer's Disease: Initiation of Thrombotic and Inflammatory Processes Via Coagulation Factor XII and Fibrinogen
… initiated by activation of the plasma protein FXII, is capable of launching both thrombotic and inflammatory pathways. I investigated whether Aβ could directly induce these pathways by interacting with FXII in vitro, in AD mouse models, and in AD patients. A prothrombotic state may also result …
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Molekulare Analyse der mRNA-Expression von Plasma-Prokallikrein
… Kininogen (LK), Faktor XI (FXI) und Faktor XII (FXII) werden dagegen nur in wenigen Geweben exprimiert. Die Transkripte von HK, LK und FXI findet man außerhalb der Leber nur noch in Nierengewebe in signifikanter Menge, während FXII-mRNA nahezu ausschließlich in der Leber synthetisiert wird. Ein …
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… mediates the conversion of factor XII (FXII) to activated factor XII (FXIIa) thereby potentiating the intrinsic pathway of coagulation. Thus, plasma kallikrein represents an important target for the development of novel anti-inflammatory and anti-thrombotic agents. The primary objective …
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Characterization of Prolylcarboxypeptidase Expression Pattern in Rat Cardiomyocytes in Nutrition Overload Conditions
… pathway. The resultant kallikrein will activate FXII which in a reciprocal manner leads to the activation of FXI. Lastly, by metabolizing α-MSH1-13 to an inactive metabolite (α- MSH1-12), PRCP inhibits the anorexigenic response to the endogenous α-MSH1-13, leading to an increase in appetite. …