Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"FVB"”.
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Charakterisierung von Stereotypien bei der FVB/NJ-Maus hinsichtlich metabolischer und immunologischer Aspekte auf die Stoffwechselleistung
… war es daher, das stereotype Verhalten der FVB/NJ-Maus erstmals detailliert zu charakterisieren, systematisch zusammenzutragen, welche metabolischen Konsequenzen dieses Verhalten bedingt und wie sich diese auf das Wohlbefinden der Tiere und die Verwendung stereotyper Tiere in Studien mit …
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Development, characterization and transcriptional profiling of a mouse model of fatal infectious diarrhea and colitis
… compared with infection in the cognate inbred FVB strain for the first time. In contrast to subclinical infection in SW mice, adult FVB mice developed overt disease with significant weight loss, severe colitis, and over 75% mortality. Fluid therapy intervention completely prevented mortality in …
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A Search For Genetic Modifiers Responsible For Congenital Heart Disease Variability In The Presence Of Nkx2-5 Haploinsufficiency
… first-generation: F1) outcrosses to the strains FVB/N or A/J. Defects recur in the second generation: F2) of the F1xF1 intercross or backcrosses to the parental strains. All 3 strains carry susceptibility alleles at different loci for atrial and ventricular septal defects. Relative to the other 2 …
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… progression and metastasis, transgenic mice FVB/N-TgN(MMTVPyVT)634Mul, developing multifocal metastasising mammary carcinomas, were utilised. CTSB deficient mice, with a mixed C57BL/6J and 129SvJ background were made congenic for the FVB/N strain. FVB/N-TgN(MMTVPyVT)-CTSB, wt, ht and ko were …
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Factors Influencing Topotecan CNS Penetration in Mouse Models
… Studies of topotecan CSF penetration in the FVB mouse using this modified approach determined that the vCSF to plasma AUC ratio of unbound topotecan lactone was greater than that previously reported using previous surgical technique. Results of studies from this lab have shown that topotecan …
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Deletion of FMR1 results in sex-specific changes in behavior.
… study, we used a systemic FMR1 knockout in an FVB background strain. We examined the effects of this genetic mutation in males and females homozygous for an FMR1 mutation on measures sociability, repetitive behaviors, vocalization patterns, anxiety and fear-related learning.
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Evaluation of age differences in locomotor activity following psychostimulant administration in adolescent versus adult mice
… inbred strains (C57BL/6J, BALB/cByJ, DBA/2J, FVB/NJ) were screened for differences in locomotor stimulation following cocaine. The greatest difference in stimulation between age groups was observed in C57BL/6J, but BALB/cByJ and female FVB/NJ mice also showed attenuated stimulation in …
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E2F1 and Tumor Suppression: The Role of P21, Mirnas, and The Dna Damage Response
… inhibited two-stage chemical carcinogenesis in FVB mice. In response to E2F1 overexpression, we found that 22 miRNAs are differentially regulated in mouse epidermis, including let-7a, let-7c, and miR-301. Additionally, regulation of miR-301 involves binding of E2F1 to its promoter. Finally, our …
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Host parasite interaction in a mouse model of inflammatory bowel disease
… progression. We have used mdrla KO mice on an FVB background toinvestigate any change in progression of colitis in mice infected with Trichuris muris. Pglycoprotein(PGP), present in the apical membrane of gut epithelial cells, is encoded by themdrla gene. This protein inhibits absorption of …
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Tobacco carcinogen induced mouse lung adenocarcinoma cell lines as tools to identify novel lung cancer genes
… adenocarcinoma cell lines from various strains (FVB and Balb/c) following repetitive exposure to the tobacco carcinogens: urethane and diethylnitrosamine. Importantly the resulting cell lines (n = 7) were immortal and phenotypically stable in vitro, oncogenic, metastatic and lethal in vivo. …
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Using Mouse Models to Define How The P53 R72P Polymorphism Impacts The Adverse Effects of Doxorubicin and Ionizing Radiation
… to an unexpected tolerance to doxorubicin in the FVB mouse strain employed, the doxorubicin studies were inconclusive. While IR did elicit a significant response, my findings did not support a role for the p53 R72P polymorphism in modulating the adverse effect IR therapy, and indicate that …
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Improving CNS Delivery of Genistein for the Treatment of Sanfilippo Syndrome
… studies were carried out on 5 groups of FVB mice (N=4) for different oral doses of unformulated genistein (5 and 50 mg/kg) and genistein nanosuspension (5, 50 and 200 mg/kg). Blood samples were analyzed using a previously validated LC-MS/MS method. Single oral dose and multiple oral dose …
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Peripheral Taste System in Inbred Mouse Strains
… taste research. Inbred mouse strains C57 and FVB have been proposed to be tasters, where as strains 129 and Balb/C are classified as non-tasters. Therefore, evaluating the peripheral taste system in these mice is of great importance to determine if there are morphological differences that …
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Beyond the Tregian Theory: Physical Analysis and Content of the Fitzwilliam Virginal Book; Egerton Ms 3665; Drexel Ms 4302; and Christ Church Mus. 510-14, Layer 2
… and European, particularly Italian, polyphony. FVB is a single multi-genre unit prepared in two Parts to presentation standards. The total 359 unica are the most valuable asset of the 4MSS. Dated concordances of non-unicas, late death dates of many composers, and similar paper types used in …
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Characterization of physicochemical properties of pan-frying bacon fat and its potential effects on breast cancer progression
… allograft mouse model BALB/c mouse strain and FVB mouse strain were selected. In each preclinical study, mice were randomly placed on diets with lard (5% fat from lard, 5% lipid from soybean oil), bacon fat (5% BF, 5% lipid from soybean oil), or a control diet with no expected cholesterol, …
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Effects of a time-restricted high- or low-fat diet on lipid absorption
… intake on lipid absorption. Methods: Adult male FVB/N mice were randomly assigned to one of 6 feeding groups (n=45, 7-8 animals/group) and kept on a strict 12h light: 12h dark feeding schedule (lights on at 10pm (Zeitgeber Time - ZT0) and lights off at 10am (ZT12)). Food was made available …
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Combination of Compounds A2CE and C18 for Cochlear Hair Cell Regeneration in Adult Mice
… injections of our drug cocktails to either FVB or Sox2 CreER; Tdtomato mice and collected their cochlea 4 weeks following injections. We found that following injections of our cocktail into the ear, regeneration of immature hair cells expressing both supporting cell markers and hair cell …
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The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis
… </p> <p> <bold>Methods</bold>: Male, wild-type, FVB strain mice were fed a nutritionally complete liquid diet supplemented with 4% ethanol v/v over a time course of 1, 2, 4, 8, 12, and 14 weeks. Changes in cardiac physiology were assessed at respective time points via echocardiography. …
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Developmental Deregulation and Tumorigenesis Inhibition In 14-3-3Zeta Knockout Mouse
… rescued when outbred to CD-1 or backcrossed to FVB/N mouse strain.</p> <p>Early mammary gland development was not significantly affected in 14-3-3z homozygous mutant mice. When crossed with MMTV driven Polyoma Middle-T or Neu oncogene transgenic tumor prone mouse, the 14-3-3z mutant mice had …
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