Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"FUS"”.
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EWSR1 and FUS fusion genes in tumorigenesis
… thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins they encode, in tumorigenesis. In Article I, the EWSR1 promoter, which regulates the expression of EWSR1 fusion genes, was characterized and regions that were crucial for promoter activity could be …
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The role of the RNA-binding protein FUS in axonal organisation and disease
The role of the RNA-binding protein FUS in axonal organisation and disease In this thesis, I discuss the role of the RNA-binding protein Fused in sarcoma (FUS) in axonal organisation and disease. FUS aggregates in forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and …
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Modeling of FUS- and C9ORF72-associated cortical neuropathology using patient-specific induced pluripotent stem cells
… mit ALS in Verbindung gebracht, einschließlich Fused in sarcoma (FUS) und Chromsosome 9 open reading frame (C9ORF72). Circa 4% der fALS Fälle sind durch dominante Mutationen in FUS verursacht und repräsentieren damit die dritthäufigste Form der fALS in Deutschland. Die G4C2 hexanucleotide repeat …
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The ALS Genes TDP-43 and FUS/TLS Regulate a Common Pathway in the Nervous System of Drosophila Melanogaster
… of ALS. Recently, two new ALS genes, TDP-43 and FUS, were identified that have structural similarities suggesting that they may function in a common process. TDP-43 and FUS have both been implicated in a number of cellular functions, including the regulation of splicing, transcription, and …
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Applications of Focused Ultrasound for Reducing Amyloid-β in a Mouse Model of Alzheimer's Disease
Focused ultrasound (FUS) can temporarily increase blood-brain barrier (BBB) permeability and locally deliver therapeutic agents to the brain. To date, applications of FUS for treatment of Alzheimer’s disease (AD) have not been explored. Here, I propose that FUS can facilitate a rapid reduction in …
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
… t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. However, the mechanism for its radiosensitivity is unknown. In order to further understand the biological …
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The Glial Response to Focused Ultrasound-mediated Permeabilization of the Blood-brain Barrier: Evaluating the Potential Contribution of Microglia and Astrocytes to Pathology and Regeneration
… in the presence of intravenous microbubbles (FUS) facilitates the non-invasive temporary permeabilization of the blood-brain barrier (BBB) for delivering therapeutics to the brain. FUS-mediated BBB modulation is known to activate microglia and astrocytes, which can exacerbate pathology or …
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Real-time beam visualization and therapy planning for focused ultrasound therapies using a diagnostic imaging array
Focused ultrasound (FUS) is a non-invasive treatment modality that can produce therapeutic effects in localized regions of tissue through thermal elevations or mechanical stresses caused by an ultrasound wave. Although FUS therapy is effective at treating many different diseases, FUS therapy can be …
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Use Of Focused Ultrasound For Transcranial Sonothrombolysis
… year. Use of transcranial focused ultrasound (FUS) for sonothrombolysis is a new research field for ischemic stroke treatment. If shown to be effective, FUS sonothrombolysis could become a widely available treatment option for the majority of the stroke sufferers that do not qualify or do not …
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Kap-[beta]2 Recognition of Cargoes Involved in Neurodegenerative/Neurodevelopmental Diseases
… such proteins of interest to my research are the Fused in Sarcoma (FUS) and the HNRNPH2 proteins that are mutated in familial ALS and Bain disease, respectively. I studied the interactions of Kapβ2 with HNRNPH2, which is mutated in the neurodevelopmental disease known as Bain disease. Mutations in …
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Immunotherapy for Alzheimer’s Disease: IVIg Delivery to the Hippocampus in a Mouse Model of Amyloidosis
… intravenously combined with focused ultrasound (FUS) to temporarily increase BBB permeability. Our hypothesis is that IVIg will enter FUS-targeted hippocampi, promote neurogenesis and decrease amyloid pathology in the TgCRND8 (Tg) mouse model of amyloidosis. In 3-month-old Tg mice, we found that …
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The effect of forepole reinforcement on tunnelling-induced movements in clay
… the effects of a Forepoling Umbrella System (FUS) that comprises steel pipes installed in a canopy shape above a tunnel heading to reduce ground movements induced by tunnelling. As an in tunnel reinforcement measure, FUS is known to be beneficial in reducing soil deformations at source and has …
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Focused ultrasound-mediated drug delivery to the brainstem
… noninvasively induce temporal BBB disruption (FUS-BBBD) at the FUS-targeted brain region, allowing the trans-BBB delivery of intravenously injected agents. Focused ultrasound-mediated intranasal delivery (FUSIN) is a newly reported technique for brain drug delivery that integrates FUS and …
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Development of MRI-compatible Transducer Array for Focused Ultrasound Surgery: : The Use of Relaxor-based Piezocrystals
Focused ultrasound surgery (FUS) is considered as a promising approach for treating cancer and other conditions and is gaining increasing interest. However, the limited availability of experimental ultrasound array sources and multichannel electronics able to drive them hinder the research into FUS …
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Methodologies for Quantifying and Characterizing Strain Fields Resulting from Focused Ultrasound Therapies in Mouse Achilles Tendon using Ultrasound Imaging and Digital Image Correlation
… studies have investigated Focused Ultrasound (FUS) for its treatment of tendons. Developments in the use of FUS as a therapeutic have led to studies of the underlying mechanisms by which it operates. Digital Image Correlation (DIC) is a non-contact method of quantifying tissue displacements and …
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Histone Post-translational Modification Dysregulation Contributes to Toxicity in Amyotrophic Lateral Sclerosis Proteinopathy Models
… that overexpression of the ALS-linked protein FUS in yeast is associated with a strong growth suppression phenotype and decreases in histone acetylation, phosphorylation and methylation. Furthermore, we show that treating these yeast with the Histone Deacetylase inhibitor Trichostatin A …
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Real time motion tracking in image guided focused ultrasound intervention
Focused ultrasound surgery (FUS) or high intensity focused ultrasound (HIFU), is a promising technique for less- or non-invasively destroying unhealthy tissue deep inside the body, without damage to the skin or surrounding tissues. The procedure has been performed under both diagnostic ultrasound …
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Focused Ultrasound Methods for the treatment of Tendon Injuries
… healing responses. Focused Ultrasound (FUS) methods are an attractive treatment option as they are non-invasive, utilize higher intensities for shorter durations and are targeted to a very specific treatment volume, hence inducing significant bio-effects in the tissue without affecting …
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