Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"FTY720"”.
-
The susceptibility of baboons to the novel immunosuppressant, FTY720
… is a need for new immunosuppressive agents. FTY720 (2 amino-2-(2-[ 4-octylphenyl] ethyl)-1,3-propanediol hydrochloride), a novel, immunosuppressive drug active in rodent and dog transplantation models, has shown no toxic side effects in pre-clinical studies although no long-term patient …
-
Sphingosine-1-Phosphate and Fingolimod (FTY720) Regulate ICl,swell In HL-1 Cardiac Myocytes via Intracellular Binding And Mitochondrial ROS Production
… by ROS-dependent signaling. S1P and its analog, FTY720 (fingolimod), primarily act via G-protein coupled receptors (S1PR; S1PR1-3 in heart), but several intracellular S1P ligands are known. We investigated how these agents regulate ICl,swell. ICl,swell was elicited by bath S1P (500 nM), FTY720 …
-
Role of Protein Phosphatase-2A in Regulating Monocyte Activation by Soluble and Crystalline Uric Acid in Gout
… growth and inflammation. The prodrug Fingolimod (FTY720) and its phosphorylated active metabolite (p-FTY720) activate intracellular PP2A. We hypothesized that monocyte activation by MSU crystals is mediated by a reduction in intracellular PP2A activity and restoring PP2A activity reduces …
-
Biological Clocks, Inflammation, and Multiorgan Damage In Sickle Cell Disease
… Berkeley sickle mice (Berkeley HBS mice), with FTY720, a US Food and Drug Administration (FDA) approved drug. FTY720 can be phosphorylated by SphK1 thus mimicking S1P to regulate S1PRs signaling. Mechanistically, FTY720 can inhibit S1PR signaling in immune cells by the internalization of the …
-
Stromal components and the control of lymphocyte trafficking in human lymph nodes
… by the egress-blocking immunosuppressive drug FTY720. These results suggest that the CD68+SGPL1+ APCs in the parenchyma may control T cell egress from human LNs, and identify a possible cellular target for FTY720. Lastly, we sought to investigate the components regulating B cell trafficking in …
-
The role of pulmonary innate and adaptive immune responses to helminth infection
… to this immunity, we used the drug Fingolimod (FTY720) to block T cell egress from lymph nodes (LN) to peripheral tissue. T cell egress from the LN was required for resolution of a primary infection but not for secondary infection. The presence of tissue-resident IL-4Rα responsive CD4+ T cells …
-
The role of pulmonary innate and adaptive immune responses to helminth infection
… to this immunity, we used the drug Fingolimod (FTY720) to block T cell egress from lymph nodes (LN) to peripheral tissue. T cell egress from the LN was required for resolution of a primary infection but not for secondary infection. The presence of tissue-resident IL-4Rα responsive CD4+ T cells …
-
Characterization of Influenza:Streptococcus pneumoniae synergistic disease and potential for disease alleviation via sphingolipid therapy
… homeostatic and influenza-infected conditions. FTY720 treatment caused transient, but significant lymphopenia, influx of neutrophils and efflux of macrophages in the lungs, which was enhanced during a mild influenza infectionGene expression in the lungs was generally unaltered, but protein …
-
The role of sphingosine kinases and dihydroceramide desaturase in cell survival/apoptosis and inflammation pathways
… as ABC294640 or SKi or K145 or (R)-methylether FTY720 (ROMe) were shown to reverse the degradation of inhibitor kappa B (IκB) and transcriptional regulation of nuclear factor kappa B (NF-κB) in response to TNFα. In contrast, the potent SK1 inhibitor, PF-543 did not reverse IκB degradation and …
-
Development of Immune Modulators Targeting Autoimmune Disorders and Pulmonary Injury: Design, Synthesis, and Biological Evaluation of Sphingolipid-Derived Sphingosine-1 Phosphate Receptor 1 Agonists
Multiple sclerosis and asthma account to the most prevalent autoimmune diseases and pose major challenges in modern medicine. The lysophospholipid–activated G protein–coupled receptor family of sphingosine-1-phosphate receptors are central regulators of the eukaryotic native as well as adaptive …