Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"FTD"”.
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Factors That Mediate Expression Of Unique Ggggcc Repeat Expansions In C9orf72-Associated Als/ftd.
… frontotemporal dementia spectrum disorders (ALS/FTD) are characterized by the degeneration of motor and cortical neurons. Recently, a hexanucleotide-repeat expansion of >30 repeats was discovered within intron 1 of C9orf72, defining ~40% of familial and ~7% of sporadic ALS/FTD cases. Aberrant …
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Investigating the role of mitochondrial dysfunction in a Drosophila model of C9orf72 ALS/FTD
… Sclerosis (ALS) and Frontotemporal Dementia (FTD). ALS is a debilitating and incurable disease characterised by the loss of upper and lower motor neurons leading to symptoms such as muscle weakness and paralysis. Most patients die from respiratory failure after 2–5 years however, only one …
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SAFTE-VAT Functionality Effects on Flight Instructors' Situation Awareness and Instrument Student Pilots' Performance during FTD Training
… air traffic to the Frasca 172S level 6 plus FTD to improve behavioral fidelity and to facilitate flight instructors the capacity to focus more on instructing student pilots instead of role-playing ATC duties. While SAFTE-VAT may offer a more realistic ATC interaction experience onboard the …
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INVESTIGATING THE ROLE OF SNAP29 AND THE AUTOPHAGY PATHWAY IN DROSOPHILA MELANOGASTER MODELS OF C9ORF72 - LINKED ALS/FTD.
… sclerosis (ALS) and frontotemporal dementia (FTD), two devastating neurodegenerative diseases, share overlapping clinical manifestations, pathogenic mechanisms, and genetic risk factors. Notably, a hexanucleotide repeat expansion of G4C2 in the non-coding region of the C9orf72 gene is …
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Positron emission tomography in vivo characterisation of the pathology of frontotemporal dementia
Frontotemporal dementia (FTD) is clinically and pathologically diverse, encompassing the behavioural variant FTD; non-fluent variant primary progressive aphasia; and semantic variant primary progressive aphasia. These are usually associated with either tau or TDP-43 pathology, with highly variable …
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Executive Functioning Component Processes and the Causes of Formal Thought Disorder in People With Schizophrenia
Formal thought disorder (FTD) is a common symptom of schizophrenia. In a review of previous research, FTD was associated with impaired executive functioning. Executive functioning encompasses potentially distinct storage and processing components. The goal of this research was to test whether FTD …
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Morphological alterations in frontotemporal dementia:
… disorder of frontotemporal dementia (FTD). With the aim to improve the clinical diagnostics of FTD, we explored the diagnostic potential of measuring morphological alterations in the white matter by diffusion tensor imaging (DTI)- MRI, compared with the more commonly used assessment of …
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Social-semantic knowledge and behavioural changes in frontotemporal dementia
… dementia, a subtype of frontotemporal dementia (FTD) associated with a degradation of conceptual knowledge following atrophy in the anterior temporal lobes (ATLs). Recent research in FTD has begun to focus on social-semantic knowledge, and its relationship to the known behavioural changes in this …
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Speech-Based Artificial Intelligence Emotion Biomarkers in Frontotemporal Dementia
… well-characterized in Frontotemporal Dementia (FTD), a heterogeneous spectrum of progressive neurodegenerative diseases that can affect speech production and comprehension as well as higher-order cognition, behavior, and motor control. While profound apathy and deficits in emotion processing are …
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Exploring perceptions of support amongst caregivers in first thousand day-friendly churches in the Western Cape
… Fund (UNICEF) (2018) the First Thousand Days (FTD) of life, which is the period from conception to two years old, is a unique window of opportunity. There is a wide body of evidence pointing to the role of stable and responsive caregiving to ensure the thriving of children. Sikunye, a …
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Blood Biomarkers of Presymptomatic Frontotemporal Dementia
Frontotemporal dementia (FTD) is characterised by neuronal loss and pathological protein inclusions in the frontal and/or temporal lobes of the brain. The presymptomatic stage, marked by molecular changes years before symptom onset, offers a critical window for early detection, intervention, …
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THE INTERPLAY BETWEEN THE PROTEIN QUALITY CONTROL SYSTEM AND EXTRACELLULAR VESICLES IN THE DISPOSAL OF DISEASE-ASSOCIATED PROTEINS AND MIRNAS IN ALS AND FTD MODELS
… Sclerosis (ALS) and Frontotemporal dementia (FTD) are two neurodegenerative diseases characterized by the presence within neurons of toxic cytoplasmic inclusions containing the insoluble forms of the TAR DNA-binding protein of 43 KDa (TDP-43) and its C-terminal fragments (CTFs) of 35 (TDP-35) …
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Origin and Role of Nuclear Somatic Mutations in Frontotemporal Dementia
… with disease states. Frontotemporal Dementia (FTD) is a young-onset form of dementia displaying great heterogeneity with respect to clinical phenotype and pathology. Several genes have been implicated in FTD, but their true mutational prevalence has been poorly understood due to the limitations …
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The Role of Progranulin in Frontotemporal Dementia
Frontotemporal dementia (FTD) is one of the most common forms of presenile dementia with a cost per patient per year greater than Alzheimer's disease. FTD is a highly heritable disease, and one of the most common genetic causes is heterozygous loss-of-function mutations in GRN, the gene that …
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A Comparison of the Frontal Variant of Alzheimer's Disease with Typical Alzheimer's Disease and Frontotemporal Dementia
… behavioral functioning in groups of AD, FvAD and FTD patients. It is predicted that the FvAD group will have an older age of onset and a lower ratio of males to females than the FTD group, and will perform similar to the AD group on measures of memory, language and visuospatial abilities. The FvAD …
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A Sensitivity Analysis of Scheduling Changes on Flight Training Resource Utilization Using Discrete Event Simulation
… available to students in Flight Training Device (FTD) course modules. Historical data from the Flight Training Department was used to build the model. As no significant difference was found between the actual real world system and the model for the number of active students and for the time it …
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Of Sex, Gut and Brain: Functional Studies in a Mouse Model of Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
… lateral sclerosis-frontotemporal dementia (ALS-FTD) is a spectrum of neurodegenerative diseases characterized by the progressive loss of the motoneurons (typical of ALS), and cognitive dysfunction (characteristic of FTD). Studies have previously identified biological sex as an important …
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Molecular mechanisms of axonal transport impairment in C9orf72-associated neurodegenerative disease
… and certain forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS or motor neuron disease). However, the cellular mechanisms that lead to impaired transport in these diseases are poorly understood. In this work I focus on the most common heritable form of ALS/FTD, which …
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UNRAVELLING THE MOLECULAR BASIS OF ALZHEIMER¿S DISEASE AND FRONTOTEMPORAL DEMENTIA: GENETIC AND EPIGENETIC APPROACH THROUGH NEXT GENERATION SEQUENCING AND OPENARRAY TECHNOLOGIES
… disease (AD) and Frontotemporal dementia (FTD) are complex heterogeneous disorders with a strong genetic background, but the identification of a genetic cause is difficult given the multifactorial aetiology of the disorders. Epigenetic and environmental factors interplay to influence this …
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The role of the RNA-binding protein FUS in axonal organisation and disease
… sclerosis (ALS) and frontotemporal dementia (FTD), and ALS-associated mutations change its phase transitions and subcellular localisation. This is known to compromise axonal local protein synthesis (LPS), but it is not well-understood which critical LPS-dependent processes are affected. This …
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