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Showing 1 to 19 of 19 for “"FT-ICR-MS"”.
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The factors and protocols that influence, accuracy, precision and uncertainty of accurate mass measurements by FT-ICR ms to validate the assignment of elemental composition
… ion cyclotron resonance mass spectrometry (FT-ICR MS) is a very powerful tool for undertaking accurate mass measurements because of its high resolving power and mass accuracy. The use of FT-ICR MS in a high-throughput environment is limited due to the need of operator intervention required …
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Novel approaches to toxicity testing in Daphnia magna
… ion cyclotron resonance mass spectrometry (FT-ICR MS) based metabolomics for use in regulatory toxicity testing. Subsequently, I aimed to use this approach to discriminate between toxicant modes of action (MOA) and to link toxicant induced metabolic effects to reduced reproductive output in …
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Profiling the metabolome using Fourier transform ion cyclotron resonance mass spectrometry, optimised signal processing, noise filtering and constraints methods
… ion cyclotron resonance mass spectrometry (FT-ICR MS). Three novel methods were developed to improve the quality of mass spectra and their interpretation. The first, SIM-stitching, combined multiple, narrow spectra into a single, wide spectrum; an approach newly adopted by several …
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Altering Nitric Oxide Bioavailability and Lipid Profiles in Endothelial Cells By Polycyclic Aromatic Hydrocarbons in Particulate Matter
… Ion Cyclotron Resonance Mass Spectrometer (FT-ICR-MS) with 12 Tesla at Old Dominion University, this study assessed how lipid peroxidation induced by PAHs altered the lipid profile and nitric oxide level in human endothelial cells.</p> <p>Human coronary artery endothelial cells (HCAEC) were …
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Comprehensive study of a heavy fuel oil spill : modeling and analytical approaches to understanding environmental weathering
… based. In the current study, samples collected after the 2007 M/V Cosco Busan heavy fuel oil spill (San Francisco, CA) were analyzed using gas chromatography (GC)-based techniques, numerical modeling and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to examine natural …
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Investigations of biological interactions by hydrogen deuterium exchange Fourier transform ion cyclotron mass spectrometry: novel methods, automated analysis and data reduction
… ion cyclotron resonance mass spectrometry (FTICR MS). For the first time, a series of oligonucleotides of varying length are interrogated by negative mode gas phase H/D exchange. Data presented describes the reactivity of these oligonucleotides and correlates reactivity to functional …
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Comprehensive study of a heavy fuel oil spill : modeling and analytical approaches to understanding environmental weathering
… based. In the current study, samples collected after the 2007 M/V Cosco Busan heavy fuel oil spill (San Francisco, CA) were analyzed using gas chromatography (GC)-based techniques, numerical modeling and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to examine natural …
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Improved mass spectrometry characterization of organic compounds using analyte preconcentration and radio-frequency ionization.
Mass spectrometry (MS) is a powerful and sensitive analytical technique that can be used for analysis of organic compounds in diverse areas of research including biomedical, environmental, and forensic sciences. Detection and identification of volatile organic compounds (VOCs) in real world …
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Fluoreszierendes gelöstes organisches Material (FDOM) in Küstenmeeren: Charakterisierung, biogeochemische Prozesse, und die Möglichkeit der in situ Überwachung
… von ultrahochauflösender Massenspektrometrie (FT-ICR-MS) mit Fluoreszenzdaten und wasserchemischen Daten kombinieren und den Ursprung des DOM in den zwei Ästuaren identifizieren. Des Weiteren habe ich zur Entwicklung neuer optische Methoden für die automatisierte Überwachung beigetragen.
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Noncovalent Interactions Between Alkali Metal Cation And Aza/thia-Crown Macrocycles: Mass Spectrometric Techniques And Theoretical Studies
… have been useful in understanding many systems encountered in biology, along with having widespread use in analytical, pharmaceutical, and synthetic chemistry. My goal was to provide a quantitative experimental and theoretical description of cation-aza-crown and thia-crown ether interactions …
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Organic Phosphorus Dynamics and Contributions to Eutrophication in a Shallow, Freshwater Bay
… cycling between both inorganic and organic forms to maintain an ecological balance. Its addition into P-scarce freshwaters, either through terrestrial (external) or sedimentary (internal) loading, may disrupt this balance causing blooms of phytoplankton to flourish, often resulting in harmful …
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Microbial Degradability of Terrigenous, Marsh-Exported, and Estuarine Colored Dissolved Organic Matter in Long Island Sound
… the production of oxygen in aquatic ecosystems. Bacteria produce and consume DOM, however spatial and temporal dynamics in the microbial availability of DOM derived from different sources in estuarine systems are not well characterized. Because of this, understanding the sources and …
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Characterization of Cucurbituril Complex Ions in the Gas Phase Using Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
… ion cyclotron resonance mass spectrometry (FT-ICR-MS) is an ideal technique for investigation of host-guest supramolecular complexes due to its ultra-high mass resolving power, ultra-high mass accuracy, and high sensitivity. Moreover it has the capability of trapping ions for ion chemistry, …
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Development of an electrospary ionization source and vacuum interface for guided ion beam tandem mass spectrometry experiments: structural and energetic effects in the molecular recognition of amino acids by 18-crown-6
… using high pressure mass spectrometry (HPMS) techniques, suggesting that the PA of 18C6 reported in the NIST Webbook and based on HPMS measurements by Kebarle and coworkers is overestimated. </p> <p>The IRMPD action spectroscopy of (B)H+(18C6) complexes are examined using a FT-ICR MS …
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Multidimensional liquid chromatographic separations for proteomics
… These methods have significant drawbacks in terms of sample bias, sample preparation and reproducibility, and therefore a new methodology that combines the positive aspects of both separation technologies in an automatable, reproducible form is highly desirable. New developments in column …
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Theoretical And Experimental Studies Of Noncovalent Metal Cation Binding And Base Pairing Interactions Of Cytosine And Modified Cytosines
… ion cyclotron resonance mass spectrometer (FT-ICR MS) coupled to a free electron laser. This work suggests that only the ground-state tautomeric conformations are accessed for all five M<sup>+</sup>(cytosine) complexes when electrospray ionization (ESI) is used as the ionization technique. …
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The versatile use of Guanidiniocarbonylpyrroles : from self-assembly to peptide recognition
… sowie auch in der Gasphase zu untersuchen. In DMSO deuten NMR-Verdünnungsreihen darauf hin, dass die flexiblen Zwitterionen mit n = 1, 3 und 5 oligomere Strukturen ausbilden. Im Falle von n = 1 werden hoch stabile helicale und Nanometer große Aggregate in der gebildet. In den Gasphasen-Studien …
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Studies Toward A Detailed Understanding Of The Intrinsic Properties Of Nucleic Acid Constituents: Gas-Phase Conformations, Energetics, And Glycosidic Bond Stability
… gas-phase conformations of the protonated forms of the nucleic acid constituents: nucleosides and mononucleotides, were characterized by infrared multiple photon dissociation (IRMPD) action spectroscopy and theoretical calculations. The IRMPD spectroscopy experiments were performed using a …