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Showing 1 to 20 of 29 for “"FT-ICR"”.
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FT-ICR- und Tandem-massenspektrometrische Untersuchungen: Gasphasenreaktionen protonengebundener Heterodimere von Dicarboxamiden
Die Arbeit beschäftigt sich mit der Bestimmung von Protonenaffinitäten von Bicyclo[2.2.1]heptandicarboxamiden zur Untersuchung intramolekularer Protonenbrücken. Weiterhin werden Ligandenaustauschreaktionen protonenverbrückter Dicarboxamid-Amin-Cluster mit dem FT-ICR-Spektrometer untersucht.
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The factors and protocols that influence, accuracy, precision and uncertainty of accurate mass measurements by FT-ICR ms to validate the assignment of elemental composition
… ion cyclotron resonance mass spectrometry (FT-ICR MS) is a very powerful tool for undertaking accurate mass measurements because of its high resolving power and mass accuracy. The use of FT-ICR MS in a high-throughput environment is limited due to the need of operator intervention required …
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Novel approaches to toxicity testing in Daphnia magna
… ion cyclotron resonance mass spectrometry (FT-ICR MS) based metabolomics for use in regulatory toxicity testing. Subsequently, I aimed to use this approach to discriminate between toxicant modes of action (MOA) and to link toxicant induced metabolic effects to reduced reproductive output in …
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Improved mass spectrometry characterization of organic compounds using analyte preconcentration and radio-frequency ionization.
… (VOCs) in real world samples, which are often present at low concentrations and within complex mixtures, require the use of efficient sampling techniques and versatile ionization sources. Presented research projects focus on the use of analyte preconcentration and radio-frequency …
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Investigations of biological interactions by hydrogen deuterium exchange Fourier transform ion cyclotron mass spectrometry: novel methods, automated analysis and data reduction
… ion cyclotron resonance mass spectrometry (FTICR MS). For the first time, a series of oligonucleotides of varying length are interrogated by negative mode gas phase H/D exchange. Data presented describes the reactivity of these oligonucleotides and correlates reactivity to functional …
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Konzeption eines kryogenen Penningfallenaufbaus für SHIPTRAP und Massenbestimmungen von Radionukliden um den Z = 82 - Schalenabschluss an ISOLTRAP
… die destruktive Flugzeitmethode (TOF-ICR) und die zerstörungsfreie Fouriertransformations-Ionenzyklotronresonanz-Methode (FT-ICR). An SHIPTRAP sind Experimente an transuranen Elementen geplant. Ihre niedrigen Erzeugungsraten stellen jedoch eine Limitierung für experimentelle …
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Profiling the metabolome using Fourier transform ion cyclotron resonance mass spectrometry, optimised signal processing, noise filtering and constraints methods
… ion cyclotron resonance mass spectrometry (FT-ICR MS). Three novel methods were developed to improve the quality of mass spectra and their interpretation. The first, SIM-stitching, combined multiple, narrow spectra into a single, wide spectrum; an approach newly adopted by several …
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Altering Nitric Oxide Bioavailability and Lipid Profiles in Endothelial Cells By Polycyclic Aromatic Hydrocarbons in Particulate Matter
… Ion Cyclotron Resonance Mass Spectrometer (FT-ICR-MS) with 12 Tesla at Old Dominion University, this study assessed how lipid peroxidation induced by PAHs altered the lipid profile and nitric oxide level in human endothelial cells.</p> <p>Human coronary artery endothelial cells (HCAEC) were …
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Dissociation, relaxation, and oxidation of highly vibrationally excited gas phase metal carbonyl and cluster anions.
… ion cyclotron resonance mass spectrometry (FT-ICR) was used to study processes occurring in highly vibrationally excited metal-containing anions. The low-pressure environment of the FT-ICR trapping cell is optimal for the intentional study of nonthermal species. Vibrationally excited anions …
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Comprehensive study of a heavy fuel oil spill : modeling and analytical approaches to understanding environmental weathering
… based. In the current study, samples collected after the 2007 M/V Cosco Busan heavy fuel oil spill (San Francisco, CA) were analyzed using gas chromatography (GC)-based techniques, numerical modeling and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to examine natural …
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Comprehensive study of a heavy fuel oil spill : modeling and analytical approaches to understanding environmental weathering
… based. In the current study, samples collected after the 2007 M/V Cosco Busan heavy fuel oil spill (San Francisco, CA) were analyzed using gas chromatography (GC)-based techniques, numerical modeling and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to examine natural …
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Characterization of Cucurbituril Complex Ions in the Gas Phase Using Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
… ion cyclotron resonance mass spectrometry (FT-ICR-MS) is an ideal technique for investigation of host-guest supramolecular complexes due to its ultra-high mass resolving power, ultra-high mass accuracy, and high sensitivity. Moreover it has the capability of trapping ions for ion chemistry, …
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Fluoreszierendes gelöstes organisches Material (FDOM) in Küstenmeeren: Charakterisierung, biogeochemische Prozesse, und die Möglichkeit der in situ Überwachung
… von ultrahochauflösender Massenspektrometrie (FT-ICR-MS) mit Fluoreszenzdaten und wasserchemischen Daten kombinieren und den Ursprung des DOM in den zwei Ästuaren identifizieren. Des Weiteren habe ich zur Entwicklung neuer optische Methoden für die automatisierte Überwachung beigetragen.
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Automated data acquisition and analysis for high-resolution Fourier transform mass spectrometry of proteins and peptides
… of the Kelleher group – a 12 tesla hybrid LTQ FT capable of analyzing hundreds of proteins per week with minimal user intervention. In early automation work centered around an 8.5 tesla hybrid quadrupole FT-ICR mass spectrometer, three strategies for automated operation of the instrument were …
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Increased confidence of metabolite identification in high-resolution mass spectra using prior biological and chemical knowledge-based approaches
… To maximise the sensitivity of the Thermo LTQ FT Ultra mass spectrometer, the existing direct-infusion SIM-stitching acquisition parameters (Southam et al., 2007) were reoptimised, yielding a ca. 3-fold increase in sensitivity. Finally, relative isotopic abundance measurements (RIA) using HR …
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Noncovalent Interactions Between Alkali Metal Cation And Aza/thia-Crown Macrocycles: Mass Spectrometric Techniques And Theoretical Studies
… ion cyclotron resonance mass spectrometer (FT-ICR MS) coupled to a wavelength tunable free electron laser (FEL). The gas phase trend suggests that binding is determined by electrostatic interactions indicating the charge density of the cation is the major feature controlling binding for the …
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Organic Phosphorus Dynamics and Contributions to Eutrophication in a Shallow, Freshwater Bay
… causing blooms of phytoplankton to flourish, often resulting in harmful environmental and anthropogenic consequences. Accordingly, reduction of external P loading has been commonly implemented with a recent focus on sediment-bound legacy P that is mobilized into the water column during dynamic …
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Microbial Degradability of Terrigenous, Marsh-Exported, and Estuarine Colored Dissolved Organic Matter in Long Island Sound
… however spatial and temporal dynamics in the microbial availability of DOM derived from different sources in estuarine systems are not well characterized. Because of this, understanding the sources and properties of dissolved organic materials coming into Long Island Sound, and their …
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Polyphosphoinositide-derived signals in the regulation of vacuole membrane fusion and fission
… the Yck3p phosphorylation sites on Vps41p by FT-ICR mass spectrometry and showed that phosphorylation of these sites was required to block vacuole fusion during hyper-osmotic stress. vps41 mutants lacking these sites showed aberrant behavior: their vacuoles underwent normal fission in response …
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