Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"FRA3B"”.
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Human common fragile sites, identification, and analysis of breaks using <i>saccharomyces cerevisiae</i>
… containing human DNA inserts from fragile sites FRA3B and FRA7H. We compared break locations with the locations of high flexibility regions and potential origins. Breaks in both FRA3B and FRA7H are located far from potential origins. These data support the second hypothesis. Breaks in FRA3B, but …
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Mechanisms and consequences of DNA damage, response and apoptosis in spermatozoa.
… the two most fragile genomic loci (fragile sites FRA3B, FRA16D) in human and murine spermatozoa with lymphocytes, significantly increased DSB levels were detected in spermatozoa in both species. This corroborates that spermatozoa are more prone to DSBs than somatic cells. When comparing the DSB …
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Mechanisms and consequences of DNA damage, response and apoptosis in spermatozoa.
… the two most fragile genomic loci (fragile sites FRA3B, FRA16D) in human and murine spermatozoa with lymphocytes, significantly increased DSB levels were detected in spermatozoa in both species. This corroborates that spermatozoa are more prone to DSBs than somatic cells. When comparing the DSB …
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The Origin of Genome Instability in Cancer: Role of the Fragile Site Gene Product FHIT
… cells is deletion within fragile site FRA3B, which overlaps exons of the large FHIT gene, resulting in loss of FHIT protein expression. Here it is shown that loss of FHIT expression triggers endogenous replication stress hindering replication fork progression and inducing fork stalling …