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Showing 1 to 2 of 2 for “"FR900098"”.
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Pathway engineering for the discovery and optimized production of phosphonic acids
… inhibitors. For the antimalarial phosphonate FR900098, a novel pathway engineering strategy, called enriched library screening, was developed that allows one to home in on top pathways in combinatorial libraries. When applied to the FR900098 pathway, a strain with a significant increase in …
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SYNTHESIS AND EVALUATION OF FOSMIDOMYCIN ANALOGUES AS ANTIMALARIAL AGENTS
… parasites. Fosmidomycin and its methyl homologue FR900098, well-known inhibitors of this enzyme that show antimalarial activity in vivo, were used as lead compounds for inhibitor design. The structure of fosmidomycin is characterized by a retrohydroxamic acid group, which acts as a ligand for the …