Global ETD Search
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Showing 1 to 5 of 5 for “"FR-900098"”.
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Directed Evolution of Phosphite Dehydrogenase and Engineered Biosynthesis of Fr-900098
… In particular, the phosphonates fosmidomycin and FR-900098 represent a new class of antimalarial compounds that can be used to inhibit the nonmevalonate pathway for isoprenoid biosynthesis in the malaria-causing parasite Plasmodium falciparum. Although no biosynthetic pathway for fosmidomycin has …
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Microbial synthesis of antimalarial compound FR-900098: pathway characterization and engineering
… with many useful therapeutic properties. FR-900098 is a novel chemotherapeutic agent for the treatment of malaria and has been effective in humans and other animals. This compound inhibits 1-deoxy-D-xylulose-5-phosphate (DXP) reductoisomerase, the second step in the nonmevalonate pathway …
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Toward the synthesis and evaluation of novel N-acylated FR-900098 analogs
… are fosmidomycin and its N-acetyl analog FR-900098, Streptomycete natural products first identified in the 1980s. These compounds were later found to be potent inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a necessary enzyme in Plasmodium for isoprenoid biosynthesis via …
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Structural studies of Butirosin D and FrbG
… re-characterized as a deacetylase, releasing a free acetate molecule when acting upon the substrate 2’-N-acetylparomamine. The involved catalytic core residues within the model are 100% conserved, as compared to the crystal structure of Orf2* in complex with its ligand teicoplanin. A triad of …
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Natural product discovery and engineering at the protein, pathway, and genome scales
… prompting pharmaceutical companies to turn away from natural products research in favor of synthetic chemistry approaches to drug discovery. Nevertheless, despite diminishing returns from traditional natural product discovery methods, modern genomics has in fact revealed that vast numbers of …