Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"FPR1 antagonists"”.
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Targeting the formyl peptide receptor 1 for treatment of glioblastoma
… reports have indicated the overexpression of FPR1 in gliomas particularly in high grade gliomas. The aim of this project was to identify and synthesise small molecule FPR1 antagonists, and to demonstrate a proof of principle in preclinical in vitro and in vivo models that small molecule FPR1 …
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Design, Synthesis and Evaluation of FPR-1 Antagonists in the Treatment of Glioma
… development. It was hypothesised that antagonists that inhibit FPR-1 may effectively treat glioblastoma. The previously synthesised antagonist, ICT12035, was potent but only exhibited a moderate ability to penetrate the BBB. Therefore, this project aimed to design and synthesise new …
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Design, Synthesis and Evaluation of FPR-1 Antagonists in the Treatment of Glioma
… development. It was hypothesised that antagonists that inhibit FPR-1 may effectively treat glioblastoma. The previously synthesised antagonist, ICT12035, was potent but only exhibited a moderate ability to penetrate the BBB. Therefore, this project aimed to design and synthesise new …