Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"FPR1"”.
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Targeting the formyl peptide receptor 1 for treatment of glioblastoma
… reports have indicated the overexpression of FPR1 in gliomas particularly in high grade gliomas. The aim of this project was to identify and synthesise small molecule FPR1 antagonists, and to demonstrate a proof of principle in preclinical in vitro and in vivo models that small molecule FPR1 …
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Determining the contribution of formylated peptides and formyl peptide receptor 1 to the pathogenesis of acute lung injury
… death and bind to formyl peptide receptor 1 (FPR1) on the neutrophil surface inducing migration and activation. Like bacterial formylated peptides they are powerful chemoattractants and are therefore likely to be important in recruiting neutrophils to sites of injury and inflammation. …
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Sexual Reproduction and Signal Transduction in the Candida Species Complex
… a synthetic lethality between hom6 and fpr1, the gene encoding FKBP12 a prolyl-isomerase that is the binding target of the immunosuppressant FK506. Thiss synthetic lethality was due to the buildup of a toxic intermediate in the methionine and threonine biosynthetic pathway as a result of …
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Design, Synthesis and Evaluation of FPR-1 Antagonists in the Treatment of Glioma
High expression of FPR-1 and its ligands are known to contribute to glioblastoma development. It was hypothesised that antagonists that inhibit FPR-1 may effectively treat glioblastoma. The previously synthesised antagonist, ICT12035, was potent but only exhibited a moderate ability to penetrate …