Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"FOXP2"”.
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Modulation of Huntington's disease-associated phenotypes by the striatal-enriched transcription factor Foxp2
… role for the striatal-enriched polyQ protein Foxp2 in HD. The transcription factor Foxp2 was recently identified as a crucial regulator of striatal synaptogenesis and corticostriatal inputs during striatal development, and has also been demonstrated to play a critical role in motor learning. …
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Understanding the Conserved and Species-Specific Functions of FOXP2, a Gene Implicated in Speech and Language Development
… the conserved and human-specific functions of FoxP2. Intrigued by the enrichment of FOXP2 in the human subplate layer, I hypothesized that FOXP2 regulates evolutionarily distinct subplate gene expression patterns and tested this theory by performing RNA-seq in human differentiating neurons and …
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Cell Type-Specific Roles of FoxP Transcription Factors in Vocalization and Cognition
… of the forkhead domain transcription factors FOXP2 and FOXP1 are highly associated with neurodevelopmental disorders affecting speech and language. Across vertebrate species, their conserved expression patterns in the developing and adult brain predict important functions in neural circuits …
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Compensation Between Foxp Transcription Factors Maintains Proper Striatal Function
… Paralogous transcription factors Foxp1 and Foxp2, which are both expressed in the dopamine receptor 1 (D1) expressing SPNs, are known to have variants implicated in NDDs. Paralogous transcription factors are thought to have the ability to compensate for each other and previous work published …
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The Evolutionary Origins of Autism Associated Genes and Their Role in Great Ape Socio-Communicative Behavior
… this study, the focus is on OXTR, AVPR1A, and FOXP2. OXTR is reported to regulate empathy and stress reactivity while AVPR1A is reported to regulate stress management and territorial aggression, as well as social bonding and recognition. FOXP2 is one of the first genes to be associated with …
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Quantitative Genexpressionsanalyse im respiratorischen Netzwerk an Mausmodellen für das Rett-Syndrom
… Evidenzen weisen daraufhin, dass Htr5b und Foxp2 ebenfalls Zielgene von MeCP2 sind und dass MeCP2 supprimierend auf deren Expression wirkt. Um die Zusammenhänge zwischen MeCP2 und seinen Zielgenen und damit auch die Pathogenese des Rett-Syndroms genauer verstehen zu können, sind jedoch noch …