Global ETD Search
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Showing 1 to 11 of 11 for “"FOXO3"”.
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Tumor suppressive effect of PARP1-FOXO3 pathway
… 저해가 암세포의 성장을 어떻게 조절하는지를 보여주었으며 PARP1저해에 의한 FOXO3의 발현 증가를 통해 종양을 억제하는 효과를 가져온다. 뿐만 아니라, 166개의 tumor stage-matched 위암 환자 샘플을 사용하여 PARP1과 FOXO3 발현을 조직 마이크로 어레이로 평가하였다. 다변량 분석을 통해 PARP1 및 FOXO3 의 발현 차이에 따른 생존 곡선을 비교한 결과, 전체 생존 기간 (overall survival, PARP1; P = 0.021, FOXO3; P = 0.001) 및 무 재발 생존 …
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The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
… the sensitivity to TACE-doxorubicin are unknown. FOXO3 is a multifunctional transcription factor that plays a role in determining cell fate in response to stress. It frequently functions as a tumor suppressor but can also promote tumor pathogenesis. FOXO3 is also known to be a mediator of …
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Análise funcional do gene FOXO3 na indução de hemoglobina fetal em células K562
… uso. O fator de transcrição Forkhead Box O 3 (FOXO3), foi descrito como um regulador fisiológico do processo maturativo eritróide e apontado como um regulador positivo dos níveis de HbF. No presente trabalho, avaliamos os níveis de expressão do gene FOXO3 em pacientes portadores de …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… Forkhead box O transcription factors FOXO1 and FOXO3 (to lesser extent) are essential for naïve and memory T cell differentiation. However, FOXO1 and FOXO3 function is not restricted to quiescent T cells; there is increasing evidence for a role in differentiation of effector T cells and in …
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… B cell homeostasis will be explored. Foxo1, Foxo3, and Foxo4 have both anti-mitogenic and pro-apoptotic properties. The transcription factors are posttranslationally controlled via Akt. When a mature B lymphocyte is stimulated through the BCR, Akt-mediated phosphorylation of Foxos results in …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… expression after PH. Four of these genes, Foxo3, Jak1, Pea15, and Tuba1 have p53 response elements (p53REs), identified in silico within the upstream regulatory region. Forkhead transcription factor Foxo3 is the most responsive gene among transcription factors with altered expression during …
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Dissecting the function and targets of FOXG1 in glioblastoma
… directly controls critical cell cycle regulators FOXO3 and FOXO6 (two forkhead family proteins), as well as the proto-oncogene MYCN and key regulators of both DNA and chromatin methylation, including TET3 and CHD3. Pharmacological inhibitors of MYC block FOXG1-driven de-differentiation, whereas …
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Genome-wide cross-cancer analysis reveals the importance of bimodal microRNA in predicting patient survival and drug response
… and miR-767 reduced levels of forkhead box O3 (FOXO3) and insulin receptor substrate 1 (IRS1). Because of the activating role of FOXO3 and IRS1 in mitogen-activated protein kinase (MAPK) signaling, levels of phosphorylated extracellular signal-regulated kinase (p-ERK) were also measured. Drug …
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Repression Of Autophagy During Erythroid Development By Gfi1b
… within several autophagy genes including <em>FOXO3, ATG5, BNIP3L,</em> <em>BNIP3 </em>and <em>ATG10</em>. Finally, to establish transcriptional regulation of select genes by GFI1B, I performed luciferase reporter assays on genomic elements following transient co-transfections into a …
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Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
… spermatogenesis, with limited contributions from Foxo3 and Foxo4. Conditional inactivation of PI3K/Akt pathway components in the male germ line confirmed that PI3K signaling regulates Foxo1 stability and subcellular localization, revealing that the Foxos are crucial effectors of PI3K/Akt signaling …
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Investigating the functions of PGC-1 isoforms in retinal pigment epithelia metabolism and their implications on age-related macular degeneration
… potentially induced in the neuro-retina, while FOXO3 was found to be downregulated. Evaluation of our novel tetracycline-inducible PGC-1β adenoviral vector showed that upregulation of PGC-1β was efficiently controlled by the addition of doxycycline to transfected cells. Upon exposure to H2O2, …