Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"FOXO1a"”.
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Herstellung und Charakterisierung einer induzierbaren Form des Transkriptionsfaktors FOXO1a
… by the insulin-regulated transcription factor FOXO1a, a 4-hydroxytamoxifen-inducible version of FOXO1a was constructed by fusing a part of the hormone-binding domain of the estrogen receptor (ER) to the C-terminus of FOXO1a (FOXO1a-ER). In HEP-G2-cells transiently transfected with plasmids …
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Investigation of plant derived compounds mediating cell signalling effectson FOXO1a and AMPK
… inactivation of the transcription factor FOXO1a, which is a major downstream effector insulin and<br/>Properties similar to the T2D drugs metformin and pioglitazone, which both activate AMOK signalling and reduce phosphorylation of the ribosomal protein S6.<br/>The project began with an …
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Die Interaktion zwischen dem Transkriptionsfaktor FoxO1a und der Proteinkinase DYRK1 und ihre Bedeutung bei der Regulation des Glucose-6-Phosphatasegens
… the kinase DYRK1 and the transcription factor FoxO1a was characterized. The role of DYRK1 in insulin-dependent regulation of hepatic glucose-production was investigated. In different independent studies in liver cells a stimulatory effect of DYRK1 on glucose-6-phosphatase (g6pase) promoter …
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Modulation of exercise-induced gene expression in human skeletal muscle by exercise intensity, training status and short-term endurance training
… larger increase in mRNA abundance of PGC-1α and FOXO1A during recovery. A single bout exercise induced an increase in PGC-1α. FOXO1A, and PDK4 mRNA abundance in both untrained and trained muscle. This may form part of a transcriptional response that contributes to exercise-induced alterations in …
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High-Resolution Array Comparative Genomic Hybridization Identifies Common Targets in Rhabdomyosarcoma
… is characterized by the presence of the PAX3/7:FOXO1A translocation. ERMS is associated with a younger age at presentation, sites of disease other than the extremities, a more favorable clinical outcome, and the absence of consistent chromosomal translocations. Here we used high-density …
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The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency
… regulation of substrate utilisation including FOXO1A and PDK4. This may form part of a transcriptional response to exercise that promotes fat oxidation and glucose sparing in the recovery from exercise. These results suggest that an acute bout of exercise induces a transient response in …
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ROLES OF HAND2 TRANSCRIPTION FACTOR IN UTERINE RECEPTIVITY AND DECIDUALIZATION
… roles of HAND2 in regulating the expression of FOXO1A, IGFBP1, BMP2 as well as WNT4. It seemed that HAND2 promoter worked in tissue specific manner and although both HOXA10 and cAMP binding sites were found in proposed HAND2 promoters, its activity was stimulated by cAMP and steroid hormones …