Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"FOXO transcription factors"”.
-
The Role of Foxo Transcription Factors in B Cell Development and Activation
… in response to BCR stimulation. A variety of factors, including signal strength and duration, cytokine presence, and co-stimulation determine the ultimate B cell fate. In this thesis, the roles Foxo transcription factors play in maintaining B cell homeostasis will be explored. Foxo1, Foxo3, …
-
Foxo Transcription Factors Control Spermatogonial Stem Cell Self-Renewal and the Initiation of Spermatogenesis
… and differentiation. Although several factors important for these processes have been identified, the fundamental mechanisms regulating SSC self-renewal and differentiation remain essentially unknown. The work presented here describes the discovery of a role for the Foxo forkhead …
-
The Endoplasmic Reticulum Udpase ENTPD5 Promotes Cancer Cell Growth and Survival in the PI3K/PTEN
… active AKT. AKT upregulates ENTPD5 by relieving transcriptional inhibition by FoxO transcription factors. ENTPD5 hydrolyzes UDP to UMP to promote protein N-glycosylation and folding in ER. Knockdown of ENTPD5 in PTEN-null cells causes ER stress and loss of receptor tyrosine kinases through …
-
Determining the Role of Trib3 in Neuronal Apoptosis
… mechanism involving Akt and its substrates, the FoxO transcription factors. It is also shown that Trib3 is transcriptionally regulated by the FoxO, JNK and apoptotic cell-cycle pathways. The data further demonstrate that Trib3 functions in a feed-forward loop with the FoxOs and deactivates Akt in …
-
Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… and promoted the expression of pro-angiogenic factors including leptin and vascular endothelial growth factor-A (VEGF-A). To investigate the potential involvement of anti-angiogenic factors in mediating the capillary remodelling response in obesity, I investigated the role of forkhead box O …
-
Effect of benzylglucosinolate on signaling pathways associated with type 2 diabetes prevention
… response to insulin. Forkhead box O (FOXO) transcription factors play a crucial role in the regulation of insulin effects on gene expression and metabolism, and alterations in FOXO function could contribute to metabolic disorders in diabetes. In this study using stably transfected …