Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"FOXG1"”.
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Dissecting the function and targets of FOXG1 in glioblastoma
… transcription factor Forkhead Box G1 (FOXG1) as the most consistently overexpressed gene in GBM-derived neural stem (GNS) cells compared to their genetically normal neural stem (NS) cell counterparts. Here we explore the function and critical downstream effectors of FOXG1 in NS and GNS …
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Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1
Forhead box G1 (FoxG1) is a winged-helix transcription factor that plays a crucial role in the development of the telecephalon, the most rostral region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their …
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The Role of MeCP2 and FoxG1 in Embryonic Cortical Development: Implications for Autism Spectrum Disorders
… development and have been implicated in ASDs are FOXG1 and MECP2. Mutations in FOXG1 cause a rare neurodevelopmental disorder known as FOXG1 syndrome, which presents with autistic features, microcephaly, and severe intellectual disability. Similarly, mutations in MECP2 cause Rett syndrome, another …
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Prion-like properties of the N-terminal domains of the rat and human FoxG1 transcription factors
… domains of the winged-helix transcription factor FoxG1.
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Regulation of the development and regeneration of the zebrafish posterior lateral line
… mutations effects on lateral line development. Foxg1 is a transcription factor in mammals that functions to promote normal development of multiple tissues including the inner ear. Murine studies demonstrate Foxg1 function is necessary for inner ear hair cell development and proper cochlear …
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Expanding the genome editing toolbox for biomedical applications
… this end, we targeted two mouse genes, Ace2 and Foxg1, via CRISPR-READI, and generated three GM mouse lines. Next, we employed Nanopore-Cas9-targeted sequencing (nCATS) to analyze the targeted sites and observed concatemer formation, along with unintended insertion of AAV’s inverted terminal …