Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"FOXC2"”.
-
Regulation of Foxc2 Expression and Function During Epithelial-Mesenchymal Transition By Gsk-3Β
… deaths. The forkhead box transcription factor FOXC2 is known to be involved in regulating metastasis as well as a variety of developmental processes, including the formation of lymphatic and cardiovascular systems. Previous studies have shown that FOXC2 protein is localized either in the …
-
The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… helix/Forkhead domain transcription factor FOXC2. We have previously shown that FOXC2 is necessary and sufficient to promote metastasis through induction of the epithelial to mesenchymal transition (EMT). EMT is a latent embryonic program that is aberrantly induced in breast cancer cells …
-
Targeting Vasculogenic Mimicry in Cancer
… a previously identified master regulator of VM, FOXC2. Next, we established a high-throughput method to sort cells for VM propensity using acetylated LDL uptake and leveraged this to conduct a genome-wide CRISPR screen using a bespoke dual gRNA-tRNA expression system. Through these approaches, we …
-
CALCIUM SENSING RECEPTOR FUNCTION IN COLON: A ROBUST PROMOTER OF DIFFERENTIATION AND TUMOR SUPPRESSOR
… vimentin, fibronectin, Snail1, Snail2, Twist and FOXC2. The expression of the tumor suppressive E-cadherin and miR145, on the other hand, was greatly reduced while the expression of oncogenic micro RNAs: miR21, miR135a and miR135b was significantly up-regulated. CaSR null cells possess a myriad of …