Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"FOXC1"”.
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Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration
… key HFSC transcription factor, Forkhead Box C1 (FOXC1), I discovered that hair follicles underwent more rounds of regeneration and yet were unable to result in a thickening of the animal's hair coat. Mechanistically, unlike WT HFSCs, FOXC1-deficient HFSCs failed to remain in prolonged durations …
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Morphological investigations into the development of the mammalian corneal endothelium using the mouse model
… squamous cells on the inner corneal surface. In Foxc1-1• mice, the CE fails to form. The understanding of the cause of this defect has implications for the study of human eye disorders that are related to FOXC1 mutations. To understand the basis of CE defects in Foxc1-1- mice, an analysis of …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… pathway positively regulates the expression of Foxc1/2. This result was further extended by the demonstration that beta-catenin occupies the chromatin upstream of Foxc1 during differentiation. Loss of functional Gli2 and Meox1 led to the downregulation of Foxc1/2, while misexpression of Gli2 …
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Identifying Oncogenic Drivers of Poor Outcome in Triple Negative Breast Cancer
… poor outcome TNBC cell lines work together with FOXC1 to subvert the growth control effects of TGFβ2-pSMAD2/3 signalling towards transcriptional activation of EMT and metastasis driving genes. Furthermore, we identified this dysregulation occurs at the protein level with GLI2 requiring to …
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The Use of Catalytically Dead Cas9 to Identify Key Transcription Regulators in Triple Negative Breast Cancer
… we focused on transcription regulators like FOXC1, NFIB and NFE2L3. We then performed RIME proteomics to identify which proteins are in close proximity to dCas9 and thus potentially bound to these putative regulatory regions. In addition, we developed a novel, statistical approach to analyse …
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Genetics of Cerebral Small Vessel Disease
… to cause familial SVD, such as COL4A1/A2, HTRA1, FOXC1 and TREX1. Genome wide association studies (GWAS) have also revealed loci associated with sporadic SVD strokes and its related features. This thesis explores the genetic basis of SVD primarily from the angle of the ‘one gene, one disease’ …
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Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics
… in SS, including AXL, ZIC2, SPAG7, AGRN, FOXC1, NCAM1. In study IV we assessed the impact of targeting peripheral versus central tumor areas using tissue microarray-based staining for Ki-67 in leiomyosarcomas and demonstrated that the Ki-67 expression was higher in the tumor periphery in …