Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"FOXA2"”.
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Ikkalpha Mediated Notch1 Activation Promotes Tumorigenesis Via Foxa2 Suppression
… of TNFa, interacts with and phosphorylates FOXA2 at S107/S111, thereby suppressing FOXA2 transactivation activity and leading to decreased NUMB expression, and further activates the downstream NOTCH pathway and promotes cell proliferation and tumorigenesis. Moreover, we found that levels of …
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Mechanistic and Physiological Studies of the Insulin-Dependent Regulation of FOXA2
<p>The Forkhead box A2 transcription factor (Foxa2/HNF-3β) has been shown to be a key regulator of genes involved in the maintenance of glucose and lipid homeostasis in the liver, and is constitutively inactivated in several hyperinsulinemic/obese mouse models, thereby enhancing their metabolic …
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Energy Homeostasis During Fasting and Fed States: Foxa2 Regulates Hepatic Amino Acid Uptake
… mice injected with adenovirus expressing either Foxa2 or GFP as a control, we found that Foxa2 mediates this insulin-sensitive increase in hepatic mNAT3 expression. Through electrophoretic mobility shift assays and chromatin immunoprecipitation experiments, we found that Foxa2 binds to promoter …
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Deciphering the mechanism of foxa2 inactivation by respiratory pathogens in chronically diseased lungs
FOXA2 is an evolutionally conserved transcription factor of forkhead box (FOX) family. FOXA2 regulates airway mucus homeostasis and acts as a transcription repressor of airway mucin5ac (MUC5AC) and mucin5b (MUC5B) genes. In diseased human and other mammalian airways, FOXA2 is inactivated in both …
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Transcriptional regulation of metastatic progression in lung adenocarcinoma
… by three transcription factors - Nkx2-1, Foxa2, and Cdx2. These three factors were highly expressed in non-metastatic cells, and downregulated in metastatic cells. Altered expression of these factors led to commensurate changes in Tks5long levels. Finally, we demonstrated that Nkx2-1, …
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Directed differentiation of endodermal cells from mouse embryonic stem cells
… definitive endoderm by expression of Sox 17 and FOXA2 and minimal expression of primitive endoderm and other germ cell layers such as ectoderm and mesoderm. These cells produced insulin and C-peptide and secreted insulin in a glucose responsive manner. However, they seem to lack mature insulin …
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Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm
… the SOX17+ population, the DE markers CER1 and FOXA2 were co-expressed in the majority cells independent of activin A treatment. By contrast, HHEX, CXCR4, FOXA2, MIXL1 and LIM1/LHX1 were expressed to various extents within the SOX17+ populations of each activin A treatment. These data provides …
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EPIGENETIC MODIFICATIONS REGULATING LIVER HOMEOSTASIS AND TUMORIGENESIS
… and H3K27Ac histone modifications on all the FoxA2 targets both on promoter and enhancers. Ultimately, cBAF complex is necessary to maintain the liver metabolism and its homeostasis. Mechanistically, ARID1A loss induced chronic inflammation and, probably indirectly, genomic instability with …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… and to co-occupy a subset of sites with FOXA1/FOXA2, promoting expression of interferon (IFN)-α/γ response genes. Inhibition of IFN-β was sufficient to attenuate iCAF-derived paracrine signalling and suppress STAT1 phosphorylation. In contrast, myCAFs promoted SOX2 upregulation in cancer cells …
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The Role of Sox17 in Normal and Pathological Beta Cell
… transcription factors including HNF1β and Foxa2, which are also known regulators of postnatal β cell function. Our data shows that Sox17 is expressed in all islet cells. Thus, we hypothesize that Sox17 is a key modulator of β cell homeostasis.</p><p>In the course of this study, we …
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The roles of T and Tbx6 during gastrulation and determination of left/right asymmetry
… have altered expression of the genes Shh, Foxa2 and Gsc, that not only mark structures of the midline and node, but whose expression is essential for the formation and patterning of these structures. Tbx6 homozygous null mutants have enlarged tail buds and ectopic neural tubes in place of …
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Effects of close-up dietary energy strategy and prepartal dietary monensin on hepatic mRNA expression of enzymes involved in glucose and lipid metabolism in transition cows
… genes (GHR, IGF1) and transcription factors (FOXA2, HNF4A, NR4A1, SREBPF2). In cows fed the CON diet, serum NEFA concentrations were higher at -2 and -1 week relative to calving and serum BHBA concentrations were also higher at -2 wk. We also observed a lower concentration of BHBA in cows fed …
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Characterization of foetal hepatic cells during rat liver development
… wie Beta-catenin, HNF4-alpha, Prox1, BMP-4, Foxa2 und GATA-4 expremieren können.Am zweiten Teil dieser Arbeit waren wir an der Entwicklung der Leber interessiert, nachdem sie als Organ identifizierbar war (von E12 zu Adultstadium). Mit Hilfe morphometrische Analyse wurde es demonstriert, dass …
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Fibronectin peptides and murine embryonic stem cells : an in vitro study
… there was a transient increase in the levels of FoxA2, a gene involved in the differentiation of embryonic stem cells into endodermal tissue. This increase was shortly followed by a significant decrease in the levels of transcripts when grown on the fibronectin peptides as opposed to gelatin …
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Derivation of next generation research models of Parkinson’s disease
… expression of combination of (ATOH1 or NGN2), FOXA2, LMX1A, NURR1, PITX3, SOX6, and MSX1 revealed three distinct TH-positive neuronal clusters. However, these neurons were also found to be positive for PRPH, a peripheral nervous system marker. The characterization of TH-positive neurons induced …