Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"FOXA1"”.
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Investigating upstream regulators of FOXA1 in breast cancer
FOXA1 is a lineage-defining transcription factor called pioneer factor. Due to its role in recruitment of nuclear receptors, such as estrogen receptor α (ERα) to enhancer regions, it is highly implicated in ERα positive breast cancer. Structural predictions of FOXA1 suggest a highly disordered …
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Monitoring the Effects of the Oncogenic S250F Mutation on the Intrinsically Disordered C-terminal of FoxA1
Forkhead box protein A1 (FoxA1) belongs to the class of pioneer transcription factors (pTFs) that have the ability to bind and open condensed chromatin and thus establish tissue-specific gene expression. FoxA1 plays a pivotal role for the correct development of various mesoderm derived tissues …
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New molecular approches using AR, FOXA1 and HER2 for outcome classification of estrogen Receptor-Positive (ER+) breast cancers”
Here, we studied new prognostic and predictive easy access strategies in breast cancer (molecular markers), for better classify ER+ breast cancer disease, which might provide additional information and be complementary to the clasical clinical-pathological prediction models.
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An In Vivo Functional Genomics Screen Identifies New Regulators of Tumorigenesis in Non-Small Cell Lung Cancer
… for tumor survival in vivo, but not in vitro: FOXA1, HDAC1, and NCOR2. None of these genes were mutated by full exome sequencing of H1819, however FOXA1 was found to be co-amplified with NKX2-1 on chromosome 14q. Here we report that NSCLC cell lines and tumor samples have significantly higher …
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Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancer
… is its accessibility to compacted chromatin. FOXA1 is a pioneer transcription factor that has the ability to bind to ‘closed’ chromatin and open it up for ERα subsequent binding, thereby creating the regulatory elements that are used by ERα. In this thesis, the dependence of the ERα hormone …
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Steroid receptor crosstalk in breast cancer cells.
… cancer development. Forkhead box protein 1 (FoxA1), a member of the forkhead class of DNA-binding proteins, has also been shown to be an important factor in breast cancer development. FoxA1 has been shown to dictate ER binding in breast cancer cells and has been deemed responsible for the …
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Investigating the transcription factor landscape of the squamous subtype of pancreatic ductal adenocarcinoma
… regulated. The well characterised pioneer factor FOXA1 was identified as a top interactor of TP63, which were further shown to co-bind at transcriptional start sites and cis-regulatory elements across the genome in a panel of human squamous PDAC cell lines. Unexpectedly GATA6 which has …
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Chromatin Architecture Aberrations Contribute and Acute Lymphoblastic Leukemia Relapse
… that converge on cis-regulatory elements for the FOXA1 gene in primary prostate tumours. We found that deletion and repression of these cis-regulatory elements significantly decreases FOXA1 expression and prostate cancer cell growth by altering the potential of transcription factors to bind at …
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The impact of ARID1A loss on ER+ breast cancer: mechanistic insights and therapeutic opportunities
… exhibit a reduced reliance on the pioneer factor FOXA1, as evidenced by a marked collapse of the FOXA1 interactome. Conversely, these tumours transitioned to a BRD3-driven state, which was recruited to newly accessible genomic regions. This recruitment promoted transcription elongation by …
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Dissecting the role of cathepsin V in breast cancer
… ERα expression and its activities. Importantly, FoxA1 and GATA3, the crucial pioneer factors of ERα transcription, were also altered in cathepsin V depleted cells; therefore, it is plausible that cathepsin V may regulate ERα expression by mediating the expression of FoxA1 and GATA3. While the …
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The role of microRNA-194 in prostate cancer progression
… at least in part by its ability to target the FOXA1 transcription factor. Importantly, targeting miR-194 effectively inhibited the growth of aggressive models of NEPC, including patient-derived organoids. By integrating the miR-194 “targetome” with transcriptomic data, my work has provided …
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An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells
… with ERα binding sites enriched in GATA and FOXA1 motifs, whereas ERβ sites being preferentially enriched in E2F motifs. In addition, in cells containing both ERα and ERβ, ERα appears to displace ERβ so that ERβ binds to sites substantially less enriched in estrogen response element (ERE) …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… regions and to co-occupy a subset of sites with FOXA1/FOXA2, promoting expression of interferon (IFN)-α/γ response genes. Inhibition of IFN-β was sufficient to attenuate iCAF-derived paracrine signalling and suppress STAT1 phosphorylation. In contrast, myCAFs promoted SOX2 upregulation in cancer …
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Simultaneous computational discovery of DNA regulatory motifs and transcription factor binding constraints at high spatial resolution
… such as c-Fos:c-Jun/USF1, CTCF/Egr1, and HNF4a/FOXA1. I also discovered a complex spatial binding relationship involved 6 key regulatory factors in mouse embryonic stem (ES) cell that is likely to be functional in ES cell gene regulation. Such computational discoveries propose testable models …
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Gene expression analysis in breast cancer
… genes across 5897 specimens identified FOXA1, SPDEF, C1ORF34 and GATA3 expression to be highly correlated. Three sub-clusters were identified among the ER-negative cluster. One represented ERBB2 over-expressing cluster. Additionally two unique groups of patients, with significant …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… agonists results in rearrangement of AR, ER, and FOXA1 cistromes, transformation of tumor suppressor AR into oncogenic AR, and activation of the JAK/STAT pathway, all culminating in lineage plasticity and resistance. This unique shift of AR into an oncogene (previously unreported for the tumor …
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Investigating PLEKHS1 adaptor function in PI3K signalling and human cancer biology
… regulators to the *PLEKHS1* locus (e.g., AR, FOXA1). To investigate PLEKHS1 adaptor protein function *in vitro*, LNCaP prostate cancer cell line is used due to its PTEN-null status and PI3K pathway hyperactivation. Transient over-expression of PLEKHS1 in LNCaP cells generates a robust …
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Characterising the role of TET2 in oestrogen receptor positive breast cancer
… several other key ER-associated proteins such as FOXA1, GREB1 and RARα. It was hypothesised that TET2, as an ER-regulated component of the ER complex, may help to sustain ER-regulated transcription in breast cancer. Consistent with a role for TET2 in mediating the proper activity of the ER …