Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"FOLFIRINOX"”.
-
Informed Decision Making for Patients with Advanced Pancreatic Cancer Considering Chemotherapy: Development and Evaluation of a Clinical Decision Aid for Patients
… (1) Best supportive care (2) gemcitabine (3) FOLFIRINOX. The objective of the decision aid was to guide patients through the decision-making process based on their individual preferences and values. The decision aid was deemed to be acceptable and feasible based on results from a pilot study …
-
Η θέση της πλήρους προεγχειρητικής χημειοθεραπείας σε οριακά εξαιρέσιμα νεοπλάσματα παγκρέατος
… Τα συχνότερα χρησιμοποιούμενα σχήματα είναι το FOLFIRINOX και τα σχήματα με βάση τη Gemcitabine, με επιλογή ανάλογα με τη γενική κατάσταση, την ηλικία και τις συννοσηρότητες του ασθενούς. Η ακτινοθεραπεία μπορεί να έχει θέση σε επιλεγμένες περιπτώσεις με σημαντική αγγειακή εμπλοκή. Παρά τα …
-
The development of next-generation antibody based therapeutics for the treatment of pancreatic cancer
… first-line chemotherapeutic combination therapy FOLFIRINOX, due to the significant toxicities associated with treatment. This highlights the urgent need for researchers to identify novel therapeutic agents capable of providing tangible patient benefit in the clinic.<br/><br/>Increasingly, …
-
Design and development of Brush-Arm Star Polymers for applications in drug delivery
… that contained the drug components of FOLFIRINOX, a combination therapy regimen for pancreatic cancer. Nanoparticle combination therapy offers the advantage of delivering combination of drugs at desired ratios in one vehicle, which may improve efficacy due to drug synergism, enhance …
-
Functional contribution of epithelial to mesenchymal transition program on KRASG12D targeting efficacy in pancreatic cancer
… chemotherapeutics such as gemcitabine, and FOLFIRINOX (fluorouracil, irinotecan, leucovorin, oxaliplatin), although these have been known for their low efficacy. The emergence of KRAS<sup>G12C </sup>inhibitors, Adagrasib and Sotorasib, paved the way for the development of MRTX1133, a …
-
Development of novel polymeric nanoparticles for pancreatic cancer therapy
… 5-fluorouracil, irinotecan and oxaliplatin (FOLFIRINOX) comes with significant toxicity and is only tolerable by some patients. Some improvement of the therapeutic index of existing chemotherapies may be achieved by encapsulation of chemotherapies inside nanoparticles (NPs) which have …
-
Development of novel antibody-targeted nanoparticle strategies for treatment of pancreatic cancer
… in pancreatic cancer treatment as part of the FOLFIRINOX regimen. <br/><br/>To improve antibody conjugation a novel N-hydroxysuccinamide endcapped polymer was employed to circumvent the need for in situ EDC functionalisation of carboxyl groups. This resulted in improved AMG 655 conjugation …
-
Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… such as Gemcitabine, 5-FU, Nab-paclitaxel and, FOLFIRINOX alone or in combination, have displayed improved but marginal survival rates for patients. Therefore, research efforts are underway to discover new therapeutic options to treat PanCa and overcome resistance to available therapies.</p> …