Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"FMRP"”.
-
FMRP dependent synaptic delivery of messenger RNA
… form of mental retardation. The loss of FMRP function results in Fragile X Mental Retardation. In this dissertation, I investigated the regulatory role of FMRP involved in synaptic mRNA delivery. In chapter 1, the molecular mechanism of local protein synthesis and synaptic mRNA delivery …
-
Role of mGluR5 and FMRP in mouse primary somatosensory cortex
… loss of fragile X mental retardation protein (FMRP). FMRP is a RNA binding protein and is hypothesised to have a role in protein trafficking from nucleus to sites of synapses, and regulating local protein synthesis at sites of synapses (Bagni and Greenough, 2005). A prevalent theory of FXS …
-
FMRP and MOV10 regulate local DICER1 expression and dendrite development
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
-
Kh Domains on Brain Polyribosomes: FMRP and Nova in Translational Regulation
… translational profiles of mice lacking Nova-1 or FMRP. The KH2 and RGG box RNA-binding domains of FMRP bind specific RNA motifs that form kissing complex and G-quartet structures, respectively. We find that the association of FMRP with polyribosomes in both mouse brain and human neuroblastoma …
-
Identification of Loss of Specific FMRP-RNA Interactions as a Cause of Fragile X Syndrome
… protein, Fragile X mental retardation protein (FMRP). This work is devoted to the understanding of functional roles of FMRP in normal neuronal development and in the pathogenesis of the Fragile X Syndrome. Particularly it focuses on the study of FMRP RNA binding properties, using both mouse …
-
Nuclear binding and translation regulation by FMRP through novel associated protein and putative RNA helicase MOV10
… dissertation focuses primarily on the role of FMRP, the fragile X mental retardation protein and its role in translational regulation. More specifically, I began my studies trying to understand the role of FMRP in the nucleus. This work is novel and interesting because the nuclear role of FMRP …
-
Molecular requirements for FMRP and RNA helicase MOV10 in the translational regulation of co-bound mRNAs
The fragile X mental retardation protein (FMRP), regulates translation of its bound mRNAs through an incompletely defined mechanism. Historically, FMRP has been known to directly associate with Argonaute (AGO), a key effector protein of the RNA induced silencing complex (RISC). MicroRNAs regulate …
-
The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation
… upregulation of neurogranin mediated by FMRP. Neurogranin was found to be regulated by the adrenergic system, and our data suggested a role in the adrenergic-mediated enhancement in memory formation and a form of synaptic plasticity known as long-term potentiation. These findings strongly …
-
Modulation of Stress Granules formation: Role of mGlu5 receptor and FMRP and implications for pathophysiology of Fragile X Syndrome
… causes the absence of the encoded protein FMRP (Fragile X Mental Retardation Protein). FMRP is an RNA-binding protein involved in mRNA transport and translation. Despite numerous studies, the available treatments are only symptomatic. There is no cure to replace FMRP expression, yet. FMRP …
-
Mechanism of Translational Control by the Fragile X Mental Retardation Protein and Creation of the FMRP CTAG Mouse
<p>The Fragile X Mental Retardation Protein (FMRP) is a neuronal RNA-binding protein that is predominantly associated with polyribosomes. Loss of FMRP results in Fragile X Syndrome, characterized by mental retardation, autism and epilepsy. FMRP was recently found to be associated with a specific …
-
Fragile X Mental Retardation Protein Induces Synapse Loss Through Acute Postsynaptic Translational Regulation
… the Fragile X Mental Retardation Protein (FMRP). FMRP is an RNA-binding protein that plays a complex role in translational regulation. FMRP may be an important regulator of dendritic protein synthesis, which occurs at or near synapses in response to synaptic activity. Many types of …
-
The Role of G-Quadruplex RNA Motif in Fragile X Syndrome
… of the fragile X mental retardation protein (FMRP). As an RNA binding protein, FMRP has been proposed to regulate the transport and translation of specific message RNA (mRNA). It has been reported that FMRP uses its RGG box domain to bind mRNA targets that form a G-quadruplex structure, …
-
Neuronal FMRP: facilitating learning in a critical brain network for zebra finch song acquisition and regulating synaptic miRNAs spatio-temporally
… expression of the normal fragile X protein FMRP, presenting with a constellation of features including intellectual disability, connective tissue abnormalities, and impaired vocalization (speech and language). FMRP is an RNA-binding protein, and animal models of FXS present with …
-
Microrna-mediated regulation and the fragile X family of proteins
… proteins, fragile X mental retardation protein (FMRP) and FXR1P, are regulated by post-translational modifications and microRNAs (miRNAs), respectively. Both proteins play key roles in normal development and function. The absence of FMRP leads to the cognitive defects seen in Fragile X syndrome, …
-
Polarizable Simulations of the bcl-2 DNA G-Quadruplex and FMRP RNA G-Quadruplex:Duplex Junction Binding Protein
… to the Fragile-X Mental Retardation Protein (FMRP) and is implicated in the development of Fragile X Syndrome (FXS). Aberrant bcl-2 GQ conformations result in increased production of the BCL2 protein, which is an apoptosis inhibitor. As such, we aim to characterize the factors stabilizing the …
-
A Study on an FMRP-Mediated Translational Switch in the MGluR-Triggered Translation of Arc and Synaptic Plasticity
… the Fragile X mental retardation protein (FMRP), a dendritic RNA-binding protein that functions, in part, as a translational suppressor. It is unknown if and how FMRP acutely regulates LTD and/or the rapid synthesis of new proteins required for LTD, such as the activity-regulated …
-
A More General Role for the Fragile X Mental Retardation Protein in Pruning of Both Synaptic and Dendritic Processes
These studies demonstrate that while FMRP does not appear to be involved in dendritic maturation it (1) does appear to be necessary for normal developmental dendritic retraction in both somatosensory whisker barrel cortex and olfactory bulb of FraX mice. Further analysis of both normal development …
-
Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice
… lower than those of wildtype mice. The role of FMRP in experience-dependent brain plasticity was also assessed. FMRP expression in the rat occipital cortex increases following exposure to a complex environment, but measures of synaptogenesis in Fmr1 knockout mice raised in this environment have …
-
Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… reports the identification of common MEF2 and FMRP mRNA targets that are required for MEF2-induced synapse elimination. The activity-dependent transcription factor myocyte enhancer factor 2 (MEF2) is a key negative regulator of excitatory synapse number, promoting synapse removal in neurons …
-
Mechanisms of transcription and translation dysfunction in disease: a novel FMRP-translation axis in Alzheimer’s and expansion of Pol III transcription in cancer
… protein Fragile X Messenger Ribonucleoprotein (FMRP). I describe a previously unrecognized mechanism by which FMRP modulates translation under amyloid-β induces toxicity, proposing FMRP as one of several factors that could influence and contribute with AD progression. Chapter 3 turns to …
Page 1 of 3