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Showing 1 to 4 of 4 for “"FKBP12.6"”.
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Untersuchung einer Calcineurin-bindungsdefizienten FKBP12.6-Mutante in Kardiomyozyten
… Aktivität gesteuert. Durch die Bindung von FKBP12.6 an den RyR2, die Isoform der Herzmuskelzelle, wird die Offenwahrscheinlichkeit des Kanals und damit der Calciumverlust in der Diastole herabgesetzt. Die durch FKBP12.6 koordiniertere Öffnung benachbarter RyR (coupled gating) bedingt zudem …
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Adenovirus-mediated gene transfer of FK506-binding proteins FKBP12.6 and FKBP12 in failing and non-failing rabbit ventricular myocytes
… Bindungsproteine (FKBP) können in Skelettmuskel (FKBP12) und Herzmuskel (FKBP12.6) die Kalziumfreisetzung aus dem sarkoplasmatischen Retikulum (SR) durch Bindung am Ryanodin Rezeptor (RyR) beeinflussen. FKBP12.6 bindet an den kardialen RyR (RyR2) und FKBP12 ausschließlich an den skelettalen RyR …
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Myocardial ischemia and reperfusion injury, clinical and experimental studies
… cells were further investigated with aspects of FKBP12 and FKBP12.6 release in hypoxia, energy depletion, acidosis, ROS activation and re-establishing of physiologic conditions, simulating ischemia and reperfusion at varying durations. Markers for inflammation increased over time, whereas the …
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The Binding Properties and Functional Consequences of Ryr2-Cam Interaction
… increase) and unchanged binding affinity for FKBP12.6-RyR2 (Kd = ~0.8nM).</p><p>The defective interaction between interdomains (the N-terminal and the central domains) is a leading hypothesis to explain the RyR2 dysfunction in HF and lethal arrhythmias, such as CPVT. And DPc10 can bind to RyR2 …