Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"FKBP12"”.
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Adenovirus-mediated gene transfer of FK506-binding proteins FKBP12.6 and FKBP12 in failing and non-failing rabbit ventricular myocytes
… Bindungsproteine (FKBP) können in Skelettmuskel (FKBP12) und Herzmuskel (FKBP12.6) die Kalziumfreisetzung aus dem sarkoplasmatischen Retikulum (SR) durch Bindung am Ryanodin Rezeptor (RyR) beeinflussen. FKBP12.6 bindet an den kardialen RyR (RyR2) und FKBP12 ausschließlich an den skelettalen RyR …
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Towards the Total Synthesis of Antascomicin B. Efforts to Construct the C1-C21 Fragment
… rapamycin and exhibits potent binding ability to FKBP12. Recent reports suggest that small molecule ligands of FKBP12 possess potent neuroprotective and neurodegenerative properties in mouse models of Parkinson's disease. Our approach to the C1-21 fragment of antascomicin B involves an asymmetric …
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THE ROLE OF ATP AND FK-506 BINDING PROTEIN IN THE COUPLED GATING OF SKELETAL RYANODINE RECEPTORS
… and attributed to FK-506 binding protein 12 (FKBP12) associating with neighboring RyR1s the stabilization of RyR1-RyR1 interactions that promote coupled gating. Previous studies suggested that ATP is required for coupled RyR1 gating; however, the mechanism by which ATP promotes the coordinated …
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Sexual Reproduction and Signal Transduction in the Candida Species Complex
… between hom6 and fpr1, the gene encoding FKBP12 a prolyl-isomerase that is the binding target of the immunosuppressant FK506. Thiss synthetic lethality was due to the buildup of a toxic intermediate in the methionine and threonine biosynthetic pathway as a result of deletion of hom6 and …
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Towards understanding EC coupling protein expression with age
… in humans. The 12kDa FK506 binding protein (FKBP12) stabilizes RyR1 in the closed state. Its dissociation from RyR1 causes a ""leaky"" channel and decreased EC coupling. Furthermore, RyR1 has two variably spliced regions, ASI and ASII, thought to be developmentally regulated. The ASI region, …
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Towards understanding EC coupling protein expression with age
… in humans. The 12kDa FK506 binding protein (FKBP12) stabilizes RyR1 in the closed state. Its dissociation from RyR1 causes a ""leaky"" channel and decreased EC coupling. Furthermore, RyR1 has two variably spliced regions, ASI and ASII, thought to be developmentally regulated. The ASI region, …
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New reporters of protein trafficking and protein-protein interactions in live cells
… detected signal upon PPI of - 5-25. Using FRB-FKBP12 system as a model, the BirA/AP(-3) pair was also able to quantitatively predict interaction KIds.
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!Development of small molecule therapeutics against anti-infectious and anti-cancer drug resistance via structure-based drug design
… structural differences between the CN-FK506-FKBP12 ternary complexes of humans and fungi and developed FK506/520 analogs targeting these complexes. The synthesized analogs retained the parent antifungal efficacy while exhibiting lower immunosuppressive activities and improved therapeutic …
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Funktionelle Charakterisierung des Komplexes aus Ornithin-Decarboxylase, Antizym und Antizym-Inhibitor sowie Identifikation einer Antizym-Inhibitor-Spleißvariante durch Bindung an FK506
… zusätzlich zu dem bekannten FK506- Bindeprotein, FKBP12, eine unbekannte, C-terminal verkürzte Spleißvariante von Antizym- Inhibitor als neuer Interaktor für FK506 identifiziert. Die Interaktion war FK506-spezifisch, da keine Interaktion mit anderen an Dexamethason gekoppelten Liganden …