Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"FICD"”.
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Post-translational regulation of BiP by FICD-mediated AMPylation and deAMPylation
… (ER)-resident, Fic domain containing protein (FICD) is able to dynamically adjust BiP’s activity through AMPylation and deAMPylation. These two mutually antagonistic reactions, catalysed by the single active site of FICD, are reciprocally regulated by an oligomeric state-dependent switch. Under …
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Fic-Mediated AMPylation in Bacterial Infection and Endoplasmic Reticulum Stress
… some of the functions of the human AMPylator, FicD, in which the targets are unclear. I found that VopS, in addition to collapsing the host actin cytoskeleton, also inhibits many aspects of host defense signaling including NFB, MAP kinases and the phagocytic NADPH oxidase system. I explored …