Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"FHA domain"”.
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Structural and functional analysis of a phospho-dependent molecular switch: Rv1827 from Mycobacterium tuberculosis
Forkhead-associated (FHA) domains have gained considerable prominence as ubiquitous phosphothreonine-dependent binding modules; however, their precise roles in Ser/Thr kinase pathways and mechanisms of regulation remain unclear. From experiments with Rv1827, an FHA domain–containing protein from …
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Investigating the Role of Pellin03 in TNF Signalling
… apoptosis in a manner that is dependent on the FHA domain but independent of the RING-like domain of Pellino3. The physiological importance of Pellino3 as a regulator of TNF signalling is confirmed by Pellino3-deficient mice showing increased sensitivity to TNF-induced apoptosis and greatly …
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Protein phosphorylation regulation in Arabidopsis
… the KAPP protein phosphatase 2C (PP2C) domain is functional in vivo; overexpressing KAPP with a mutation in the PP2C domain (D346G) creates a dominant negative effect and the transgenic plants have a pleiotropic phenotype. Fork-head associated (FHA) domain-mediated protein-protein …
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Role of Phosphorylation In The Regulation of Prmt5
… the interaction of PRMT5 with several SH2-domain containing proteins, 14-3-3 proteins and the FHA domain of MDC1. These novel phospho-dependent PRMT5 interactions suggest that crosstalk between kinases and arginine methyltransferases may play a pivotal role in modulating the different …
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Untersuchungen zur Expression und subzellulären Lokalisation von Isoformen des Adaptorproteins Kanadaptin
… Extension konnte eine Gabelkopfdomäne (FHA-Domäne) identifiziert werden. FHA-Domänen sind phosphorylierungsabhängige Protein-Protein-Bindedomänen und finden sich hauptsächlich in nukleären Proteinen. Basierend auf diesen Erkenntnissen, lag der Fokus im zweiten Teil der Arbeit auf …