Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"FGFR4"”.
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Untersuchungen zur Funktion der Rezeptortyrosinkinase FGFR4 in der Tumorentwicklung
… die Funktion der Rezeptor Tyrosin Kinase (RTK) FGFR4 (Fibroblast Growth Factor Rezeptor 4) in der Tumorentwicklung untersucht. Der FGFR4 besteht aus einer extrazellulären ligandenbindenen Domäne, einer einspännigen Transmembrandomäne und einem intrazellulären Bereich, der neben zwei …
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The Role of FGFR4 in Trigeminal Placode Cell Development
… development of the peripheral nervous system. FGFR4 is expressed transiently in the trigeminal placode as cells undergo an epithelial-mesenchymal transition and begin to migrate toward the condensing ganglion. Because of the restricted spatiotemporal expression of FGFR4 in the opV placode, it …
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The Role of Acidic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor 4 In High Grade Serous Carcinoma
… value of fibroblast growth receptor 4 (<em>FGFR4</em>), another candidate gene of the FGF/FGFR axis located in the same amplicon. The emphasis will be delineating the role the FGF1/FGFR4 signaling axis plays in high grade serous ovarian carcinoma; and test the feasibility of targeting the …
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
… and skeletal development in zebrafish, whereas Fgfr4 is required for pectoral fin specification and growth.
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MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B
… chondrocytes through the activation of FGFR3 and FGFR4 receptors, which in turn inhibit the PI3K/Akt-mTORC1 pathway and promote TFEB/TFE3 nuclear translocation and enhance Fam134b transcription. Notably, FAM134B is required for protein secretion in chondrocytes. In conclusion, this study …
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THE ROLE OF BETA-KLOTHO PROTEIN IN NAFLD PATHOGENESIS
… for fibroblast growth factor receptors 4 (FGFR4), mediates in the liver the hormonal activity of FGF19 and plays a central role in the regulation of lipid metabolism and in bile acids’ biosynthesis. Thus, a stable KLB full knock-out model in HepG2 hepatoma cells (KLB-/-) has been generated …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… acts at the liver where it binds to the membrane FGFR4/βKL receptor complex and mediates postprandial responses under normal physiological conditions. However, hepatic miR-34a is highly elevated in the obese state which results in repressed βKL expression, impaired FGF19-activated Erk signaling, …