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Showing 1 to 11 of 11 for “"FGFR3"”.

  1. Discovery and Elucidation of The Fgfr3-Tacc3 Recurrent Fusion In Glioblastoma

    Parker Kerrigan, Brittany C2015

    … growth factor receptor 3</em> (<em>FGFR3</em>) gene to the<em> transforming coiled-coil containing protein 3 </em>(<em>TACC3</em>) gene in glioblastoma multiforme. The fusion occurred in 8.3% of patient samples, but not in low grade or normal samples. <em>FGFR3-TACC3 </em>produced an …

    uthsc Repository record

  2. Identification of T cell receptors targeting a neoantigen derived from recurrently mutated FGFR3

    Tate, TomohiroKyoto University2023

    kyoto Repository record

  3. Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma

    Thevasagayampillai, Shiyanth 1994-University of Houston2026

    This study investigates the FGFR3-TACC3 fusion as a tumor-specific neoantigen source and establishes an end-to-end computational and experimental framework for the identification, prioritization, and validation of immunogenic neoantigens derived from chimeric RNAs. The FGFR3-TACC3 fusion, generated …

    houston Repository record

  4. Mechanisms Underlying Distinct Egfr Versus Fgfr-3 and -1 Dependency In Human Bladder Cancer Cells

    Cheng, Tiewei2015

    … inhibitors in BC cells, we demonstrated that FGFR3 and FGFR1 play largely non-overlapping roles in mediating proliferation and invasion in the distinct “epithelial” and “mesenchymal” subsets of human BC cells. Furthermore, we examined the sensitivities to FGFR3 and EGFR inhibition in a panel …

    uthsc Repository record

  5. MOLECULAR PROFILING OF UROTHELIAL CARCINOMA

    Lindgren, DavidDivison of Clinical Genetics, Lund University2006

    … and tumor stage/grade, or mutation status of FGFR3/TP53 and LOH for chromosome 9. It was shown that the mutational status of FGFR3 and TP53 correlated with large transcriptional differences, thus indicating for two different molecular pathways of UC development. Furthermore, we found gene …

    lund Repository record

  6. FGF signaling in Xenopus laevis lens regeneration

    Moore, LisaUniversity of Illinois at Urbana-Champaign2015

    … Three receptor mRNAs (FGFR1, FGFR2, and FGFR3) were found to be expressed in the cornea. Second, the necessity of FGFR signaling was investigated in vitro using a small molecule inhibitor (SU5402) and dominant negative FGFR1. Both experiments demonstrated that lens regeneration is …

    uiuc Repository record

  7. MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B

    IAVAZZO, MARIAUniversità degli Studi di Milano2022

    … in chondrocytes through the activation of FGFR3 and FGFR4 receptors, which in turn inhibit the PI3K/Akt-mTORC1 pathway and promote TFEB/TFE3 nuclear translocation and enhance Fam134b transcription. Notably, FAM134B is required for protein secretion in chondrocytes. In conclusion, this study …

    milano Repository record

  8. An Integrated Bioinformatics Approach for the Identification of Melanoma-Associated Biomarker Genes. A Ranking and Stratification Approach as a New Meta-Analysis Methodology for the Detection of Robust Gene Biomarker Signatures of Cancers.

    Liu, WantingUniversity of Bradford2015

    … for melanoma was defined (i.e., EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, CHP2, SHC4, PPP2R2C, and WNT4). Of these, CXCL13, COL11A1, PTPRF and SHC4 are components of the MAPK pathway and were validated by immunocyto- and immunohisto-chemistry. These proteins were found to be …

    bradford Repository record

  9. Downregulation of miRNA expression in malignant germ cell tumours: mechanism and functional significance

    Ferraresso, MartaUniversity of Cambridge2019

    … focussed in particular on TRIM71, FGFR3, E2F7 and LIN28A. Moreover, restoring miR-99a-5p/-100-5p and miR-125b-5p in TCam2 cells also resulted in G0-G1 accumulation, consistent with a cell cycle effect. These data support a functionally important role for miR99a-5p/-100-5p and …

    cambridge Repository record

  10. Pan-Cancer Genomic Characterization of Human Papillomavirus Associated Tumors

    Holt, Jeremiah Ray2025

    … prevalent in HNSC tumors. Across HPV(+) tumors, FGFR3 hotspot mutations were more frequent in HNSC, NFE2L2 hotspots occurred more in CESC and integrated tumors, and PTEN mutations occurred more often in females compared to males. Deletions of chromosome 11q22 frequently occurred in HPV(+) HNSC to …

    tenn-hsc Repository record

  11. Structural and Functional Characterisation of the Nutrient Sensing Kinase GCN2

    Inglis, AlisonUniversity of Cambridge2018

    A cell’s ability to recognise and respond to changes in its environment is crucial to its survival. The availability of nutrients is a fundamental part of the environment, and so cells must be able to identify when they are plentiful and when they are scarce, and adapt accordingly. GCN2 is a key …

    cambridge Repository record