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Showing 1 to 2 of 2 for “"FGFR signalling"”.

  1. Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened

    Gustafsson, RenataLund University, Faculty of Medicine2008

    … occurring in early embryogenesis. Among several signalling pathways and inductive factors, the fibroblast growth factors (FGFs) and their receptors (FGFRs) have been shown to be important during early embryogenesis. Previously it has been shown that ESCs expressing a mutant form of FGFR failed to …

    lund Repository record

  2. Signalling and transcriptional regulation of human primordial germ cell specification

    Sybirna, AnastasiyaUniversity of Cambridge2020

    … experimentally by modulating the candidate signalling pathways in competent hESCs, followed by hPGCLC induction. I found that inhibition of FGF receptor (FGFR) or its downstream effectors (MEK and PI3K) enhanced competency for PGC fate. By contrast, premature MEK/ERK activation in hESCs …

    cambridge Repository record