Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"FGFR signaling"”.
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FGF signaling in Xenopus laevis lens regeneration
… examines the relationship between FGF signaling and lens regeneration, exploring the hypothesis that the FGF signaling plays a key role in triggering lens regeneration. First, the mRNA expression levels of FGFs and FGFRs in the cornea and retina were observed, as the key ligand from the …
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Investigating fibroblast growth factor and its role in canine osteosarcoma
… tumor microenvironment contains many cells and signaling molecules such as cytokines, chemokines and growth factors. Investigating these factors may identify a stimulus for a less differentiated and more aggressive neoplasia. This is even more compelling if the stimulus is a druggable target. …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… to better understand the mechanisms by which Fgf signaling regulates pattern formation and embryogenesis. I addressed this question on several levels, investigating the extent of intracellular signaling (MAPK activation) relative to sources of Fgf expression, and the transcriptional responses of …
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Diacylglycerol lipaseα-dependent endocannabinoid signaling in neural stem cells
… and growing evidence points to a role of eCB signaling in adult neurogenesis as well as a wide range of different physiological roles in the brain. The focus of this thesis is on DAGL driven eCB signaling in neural stem cells (NSC). A role of the eCB system has previously been established in …
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I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… imaging of noradrenergic modulation of cortical signaling networks. NG54, a FFN with substrate activity at each of the monoamine transporters was also identified, and represents a new structural class of FFNs. In Chapter 4, APP+, a known fluorescent substrate for the monoamine transporters, is …
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The human Klotho VS variant: focus on the processing and function of the V, S and VS isoforms
… of KL deficient mice and its connection to signaling pathways implicated in aging. The KLVS variant consists of the F352V (KLV) and C370S (KLS) substitutions. It was detected in genome wide association studies (GWAS) that linked it to alterations in longevity and disease risk. The molecular …